CH TECHNOLOGIES  |  PUBLICATIONS

AeroBiology and Biodefense

2001

           Elisabeth J. Ruijgrok, Arnold G. Vultob and Els W. M. Van Etten. Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats. J. Antimicrob. Chemother. (2001) 48 (1): 89-95.

2004

           Charles A. Scanga, Andre Bafica, Carl G. Feng, Allen W. Cheever, Sara Hieny and Alan Sher. MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression. Infect. Immun. April 2004 vol. 72 no. 4 2400-2404.

           Xuejun J. Yin, Caroline C. Dong, Jane Y. C. Ma, James M. Antonini, Jenny R. Roberts, Charles F. Stanley, Rosana Schafer and Joseph K. H. Ma. Suppression of Cell-Mediated Immune Responses to Listeria Infection by Repeated Exposure to Diesel Exhaust Particles in Brown Norway Rats. Toxicol. Sci. (2004) 77 (2): 263-271.

           Pilar Domenech, Michael B. Reed, Cynthia S. Dowd, Claudia Manca, Gilla Kaplan and Clifton E. Barry III. The Role of MmpL8 in Sulfatide Biogenesis and Virulence of Mycobacterium tuberculosis. The Journal of Biological Chemistry, Vol. 279, No. 20, 2004, pp. 21257–21265.

           Alison K. Pickering, Manuel Osorio, Gloria M. Lee, Vanessa K. Grippe, Mechelle Bray and Tod J. Merkel. Cytokine Response to Infection with Bacillus anthracis Spores. Infect. Immun. November 2004 vol. 72 no. 11 6382-6389.

2005

           Eric T. Harvill, Gloria Lee, Vanessa K. Grippe and Tod J. Merkel. Complement Depletion Renders C57BL/6 Mice Sensitive to the Bacillus anthracis Sterne Strain. Infect. Immun. July 2005 vol. 73 no. 7 4420-4422.

           Molly A. Hughes, Candace S. Green, Lisa Lowchyj, Gloria M. Lee, Vanessa K. Grippe, Michael F. Smith Jr., Li-Yun Huang, Eric T. Harvill and Tod J. Merkel. MyD88-Dependent Signaling Contributes to Protection following Bacillus anthracis Spore Challenge of Mice: Implications for Toll-Like Receptor Signaling. Infect. Immun. November 2005 vol. 73 no. 11 7535-7540.

           Gediminas Mainelis, David Berry, Hey Reoun An, Maosheng Yao, Kevin DeVoe, Donna E. Fennell, Rudolph Jaeger. Design and performance of a single-pass bubbling bioaerosol generator. Atmospheric Environment, Volume 39, Issue 19, June 2005, Pages 3521–3533.

2006

           Liana Tsenova, Ryhor Harbacheuski, Evette Ellison, Claudia Manca, and Gilla Kaplan. Aerosol Exposure System for Rabbits: Application to M. Tuberculosis Infection. Applied Biosafety, 2006, 11 (1) pp. 7-14.

2007

           Crystal L. Loving, Mary Kennett, Gloria M. Lee, Vanessa K. Grippe and Tod J. Merkel. Murine Aerosol Challenge Model of Anthrax. Infect. Immun. June 2007 vol. 75 no. 6 2689-2698.

           Lida Mohtasham, Alexander Auais and Giovanni Piedimonte. Nerve growth factor mediates steroid-resistant inflammation in respiratory syncytial virus infection. Pediatric Pulmonology, Volume 42, Issue 6, pages 496–504, June 2007.

           Dennis M. Klinman, Debra Currie, Gloria Lee, Vanessa Grippe and Tod Merkel. Systemic but not mucosal immunity induced by AVA prevents inhalational anthrax. Microbes and Infection, Volume 9, Issues 12–13, October 2007, Pages 1478–1483.

2009

           Crystal L. Loving, Taruna Khurana, Manuel Osorio, Gloria M. Lee, Vanessa K. Kelly, Scott Stibitz and Tod J. Merkel. Role of Anthrax Toxins in Dissemination, Disease Progression, and Induction of Protective Adaptive Immunity in the Mouse Aerosol Challenge Model. Infect. Immun. January 2009 vol. 77 no. 1 255-265.

           Crystal L. Loving, Manuel Osorio, Yun-Gi Kim, Gabriel Nuñez, Molly A. Hughes and Tod J. Merkel. Nod1/Nod2-Mediated Recognition Plays a Critical Role in Induction of Adaptive Immunity to Anthrax after Aerosol Exposure. Infect. Immun., October 2009, vol. 77, no. 10, 4529-4537.

           D. Saini, R. M. Buller, A. S. Biris and P. Biswas. Characterization of a Nose-Only Inhalation Exposure System for Ectromelia Virus Infection of Mice. Particulate Science and Technology: An International Journal, Volume 27, Issue 2, 2009, p.152-165.

           Shanshan Cai, Rachel L. Zemans, Scott K. Young, G. Scott Worthen, and Samithamby Jeyaseelan. Myeloid Differentiation Protein-2–Dependent and –Independent Neutrophil Accumulation during Escherichia coli Pneumonia. Am J Respir Cell Mol Biol. Jun 2009; 40(6): 701–709.

           Jorrit J Hofstra, Alexander D Cornet, Bart F de Rooy, Alexander P Vlaar, Tom van der Poll, Marcel Levi, Sebastian AJ Zaat and Marcus J Schultz. Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumonia pneumonia in rats. Critical Care, 2009, 13:R145.

           Marco Zaru, Chiara Sinico, Alessandro De Logu, Carla Caddeo, Francesco Lai, Maria Letizia Manca, Anna Maria Fadda. Rifampicin-loaded liposomes for the passive targeting to alveolar macrophages: in vitro and in vivo evaluation. Journal of Liposome Research, March 2009, Vol. 19, No. 1, Pages 68-76.

           Manuel Osorio, Yanping Wu, Sunil Singh, Tod J. Merkel, Siba Bhattacharyya, Milan S. Blake and Dennis J. Kopecko. Anthrax Protective Antigen Delivered by Salmonella enterica Serovar Typhi Ty21a Protects Mice from a Lethal Anthrax Spore Challenge. Infect. Immun. April 2009 vol. 77 no. 4 1475-1482.

2010

           Richard S Tuttle, William A Sosna, Deirdre E Daniels, Sara B Hamilton and John A Lednicky. Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferrets. Virology Journal 2010, 7:135.

           John A Lednicky, Sara B Hamilton, Richard S Tuttle, William A Sosna, Deirdre E Daniels, David E Swayne. Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1). Virology Journal 2010, 7:231.

           Padmapriya P. Banada, Satheesh K. Sivasubramani, Robert Blakemore, Catharina Boehme, Mark D. Perkins, Kevin Fennelly and David Alland. Containment of Bioaerosol Infection Risk by the Xpert MTB/RIF Assay and Its Applicability to Point-of-Care Settings. J. Clin. Microbiol. October 2010 vol. 48 no. 10 3551-3557.

           Lisa A. Morici, Julie Heang, Tim Tate, Peter J. Didier, Chad J. Roy. Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection. Microbial Pathogenesis, Volume 48, Issue 1, January 2010, Pages 9–17.

           Olga B. Garbuzenko, Maha Saad, Vitaly P. Pozharov, Kenneth R. Reuhl, Gediminas Mainelis and Tamara Minko. Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance. PNAS, June 8, 2010, vol. 107,| no. 23: 10737–10742.

2011

           Zhenqiang Xua, Yan Wua, Fangxia Shena, Qi Chena, Miaomiao Tana & Maosheng Yaoa. Bioaerosol Science, Technology, and Engineering: Past, Present, and Future. Aerosol Science and Technology, Volume 45, Issue 11, 2011.

           Kerstin J. Williams, Helena I. Boshoff, Nitya Krishnan, Jacqueline Gonzales, Dirk Schnappinger, Brian D. Robertson. The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. Tuberculosis, Volume 91, Issue 6, November 2011, Pages 549–555.

           Douglas S. Reed, Le'Kneitah Smith, Tammy Dunsmore, Anita Trichel, Luis A. Ortiz, Kelly Stefano Cole, Eileen Barry. Pneumonic Tularemia in Rabbits Resembles the Human Disease as Illustrated by Radiographic and Hematological Changes after Infection. PLoS ONE, 2001, 6(9): e24654. doi:10.1371/journal.pone.0024654.

           Wildaliz Nieves, Saja Asakrah, Omar Qazi, Katherine A. Brown, Jonathan Kurtz, David P. AuCoin, James B. McLachlan, Chad J. Roy, Lisa A. Morici. A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection. Vaccine, Volume 29, Issue 46, 26 October 2011, Pages 8381–8389.

           Brendan Prideaux, Véronique Dartois, Dieter Staab, Danielle M. Weiner, Anne Goh, Laura E. Via, Clifton E. Barry III, and Markus Stoeckli. High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions. Analytical Chemistry, 2011, 83 (6), pp 2112–2118.

           Selvakumar Subbian, Liana Tsenova, Paul O'Brien, Guibin Yang, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Jerome B. Zeldis, George Muller, Gilla Kaplan. Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology. The American Journal of Pathology, Volume 179, Issue 1, July 2011, Pages 289–301.

2012

           Maria C. Kjellssona, Laura E. Via, Anne Goh, Danielle Weiner, Kang Min Low, Steven Kern, Goonaseelan Pillai, Clifton E. Barry III and Véronique Dartois. Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions. Antimicrob. Agents Chemother. January 2012 vol. 56 no. 1 446-45.

           Guoyan Cheng, Xiaomei Yuan, Matthew S. Tsai, Eckhard R. Podack, Aixin Yu and Thomas R. Malek. IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells. The Journal of Immunology August 15, 2012 vol. 189 no. 4 1780-179.

           Chad J. Roy, Satheesh K. Sivasubramani, Noton K. Dutta, Smriti Mehra, Nadia A. Golden, Stephanie Killeen, James D. Talton, Badre E. Hammoud, Peter J. Didier and Deepak Kaushal. Aerosolized Gentamicin Reduces the Burden of Tuberculosis in a Murine Model. Antimicrob. Agents Chemother. February 2012, vol. 56, no. 2:883-886.

           Nicole N. Driessen, Helena I. M. Boshoff, Janneke J. Maaskant, Sebastiaan A. C. Gilissen, Simone Vink, Astrid M. van der Sar, Christina M. J. E. Vandenbroucke-Grauls, Carole A. Bewley, Ben J. Appelmelk and Jeroen Geurtsen. Cyanovirin-N Inhibits Mannose-Dependent Mycobacterium–C-Type Lectin Interactions but Does Not Protect against Murine Tuberculosis. The Journal of Immunology October 1, 2012 vol. 189 no. 7 3585-3592.

           Susan T. Gater, Kristen N. Peters, Andrew G. Kocsis, Miqdad O. Dhariwala, Deborah M. Anderson, and Paul E. Anderson.. Host stress and immune responses during aerosol challenge of Brown Norway rats with Yersinia pestis. Front Cell Infect Microbiol. 2012; 2: 147.

           Seth A.Faith, Le'Kneitah P. Smith, Angela S. Swatland, Douglas S. Reed. Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice. Frontiers in Cellular & Infection Microbiology. Sep 2012, Vol. 2, p2-36. 35p.

           R.S. McDonald, A.R. Sambol, B.K. Heimbuch, T.L. Brown2, S.H. Hinrichs and J.D. Wander. Proportional mouse model for aerosol infection by influenza. Journal of Applied Microbiology, Volume 113, Issue 4, pages 767–778, October 2012.

           B.R. Stone, B.K. Heimbuch, C.-Y. Wu and J.D. Wander. Design, construction and validation of a nose-only inhalation exposure system to measure infectivity of filtered bioaerosols in mice. Journal of Applied Microbiology, Volume 113, Issue 4, pages 757–766, October 2012.

           Scott Parker, Nanhai G. Chen, Scott Foster, Hollyce Hartzler, Ed Hembrador, Dennis Hruby, Robert Jordan, Randall Lanier, George Painter, Wesley Painter, John E. Sagartz, Jill Schriewer, R. Mark Buller. Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox – An animal model of smallpox. Antiviral Research, Volume 94, Issue 1, April 2012, Pages 44–53.

           Laura E. Via, Dan Schimel, Danielle M. Weiner, Veronique Dartois, Emmanuel Dayao, Ying Cai, Young-Soon Yoon, Matthew R. Dreher, Robin J. Kastenmayer, Charles M. Laymon, J. Eoin Carny, JoAnne L. Flynn, Peter Herscovitch and Clifton E. Barry III. Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [18F]2-Fluoro-Deoxy-d-Glucose Positron Emission Tomography and Computed Tomography. Antimicrob. Agents Chemother. August 2012, vol. 56, no. 8:4391-4402.

           Lisa N. Henning, Karen T. Gillum, David A. Fisher, Roy E. Barnewall, Robert T. Krile, Michael S. Anderson, Michael J. Ryan & Richard L. Warren. The Pathophysiology of Inhalational Brucellosis in Balb/c Mice. Sci. Rep. 2, 495; DOI:10.1038/srep00495 (2012).

           Daniel Verreault, Satheesh K. Sivasubramani, James D. Talton, Lara A. Doyle, Joseph D. Reddy, Stephanie Z. Killeen, Peter J. Didier, Preston A. Marx, Chad J. Roy. Evaluation of inhaled cidofovir as postexposure prophylactic in an aerosol rabbitpox model. Antiviral Research, Volume 93, Issue 1, January 2012, Pages 204–208.

2013

           Laura E. Via, Danielle M. Weiner, Daniel Schimel, Philana Ling Lin, Emmanuel Dayao, Sarah L. Tankersley, Ying Cai, M. Teresa Coleman, Jaime Tomko, Praveen Paripati, Marlene Orandle, Robin J. Kastenmayer, Michael Tartakovsky, Alexander Rosenthal, Damien Portevin, Seok Yong Eum, Saher Lahouar, Sebastien Gagneuxj, Douglas B. Young, JoAnne L. Flynn and Clifton E. Barry III. Differential Virulence and Disease Progression following Mycobacterium tuberculosis Complex Infection of the Common Marmoset (Callithrix jacchus). Infect. Immun. August 2013, vol. 81, no. 8:2909-2919.

           Vladimir Savransky, Daniel C. Sanford, Emily Syar, Jamie L. Austin, Kevin P. Tordoff, Michael S. Anderson, Gregory V. Stark, Roy E. Barnewall, Crystal M. Briscoe, Laurence Lemiale-Biérinx, Sukjoon Park, Boris Ionin and Mario H. Skiadopoulos. Pathology and Pathophysiology of Inhalational Anthrax in a Guinea Pig Model. Infect. Immun. April 2013 vol.

           John T. James, Chiu-Wing Lam, Patricia A. Santana, and Robert R. Scully. Estimate of safe human exposure levels for lunar dust based on comparative benchmark dose modeling. Inhalation Toxicology, April 2013, Vol. 25, No. 5 , Pages 243-256.

2014

           Amy L. Hartman, Diana S. Powell, Laura M. Bethel, Amy L. Caroline, Richard J. Schmid, Tim Oury and Douglas S. Reed. Aerosolized Rift Valley Fever Virus Causes Fatal Encephalitis in African Green Monkeys and Common Marmosets. J. Virol. February 2014 vol. 88 no. 4 2235-2245.

           Douglas S. Reed, Le’Kneitah P. Smith, Kelly Stefano Cole, Araceli E. Santiago, Barbara J. Mann and Eileen M. Barry. Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain. Infection and Immunity, April 2014, volume 82, issue 4.

           Huajun Zhen, Taewon Han, Donna E. Fennell, Gediminas Mainelis. A systematic comparison of four bioaerosol generators: Affect on culturability and cell membrane integrity when aerosolizing Escherichia coli bacteria. Journal of Aerosol Science, Volume 70, April 2014, Pages 67–79.

           Maria C. Kjellsson, Laura E. Via, Anne Goh, Danielle Weiner, Kang Min Low, Steven Kern, Goonaseelan Pillai, Clifton E. Barry III and Véronique Dartois. Penetration of anti-tuberculosis agents in rabbit pulmonary lesions: a pharmacokinetic evaluation. Antimicrobial Agents and Chemotherapy, April 2014, volume 58, issue 4.

           Brandon Feinen, Nikolai Petrovsky, Anita Verma and Tod J. Merkel. Advax-Adjuvanted Recombinant Protective Antigen Provides Protection against Inhalational Anthrax That Is Further Enhanced by Addition of Murabutide Adjuvant. Clin Vaccine Immunol, April 2014, vol. 21, no. 4:580-586.

           Olga B. Garbuzenko, Gediminas Mainelis, Oleh Taratula, Tamara Minko. Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention. Cancer Biol Med 2014;11:44-55.

           David E Harrison, Clinton M Astle, M Khalid Khan Niazi, Samuel Major and Gillian L Beamer. Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis. Immunity & Ageing (2014) 11:24, DOI 10.1186/s12979-014-0024-6.

           Xuan Qiu, Yuanxin Liang, Rani S. Sellers, Roman Perez-Soler, Yiyu Zou. Aerosol Azacytidine Inhibits Orthotopic Lung Cancers in Mice through Its DNA Demethylation and Gene Reactivation Effects. PLoS ONE 9(10): e109874. doi:10.1371/journal.pone.0109874.

           Sasha J. Rose, Mary E. Neville, Renu Gupta, Luiz E. Bermudez. Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection. PLoS ONE 9(9): e108703. doi:10.1371/journal.pone.0108703.

           Simone R. Carvalho, Alan B. Watts, Jay I. Peters, Sha Liua, Soraya Hengsawas, Manuel S. Escotet-Espinoza, Robert O. Williams III. Characterization and pharmacokinetic analysis of crystalline versus amorphous Rapamycin dry powder via pulmonary administration in rats. European Journal of Pharmaceutics and Biopharmaceutics, Volume 88, Issue 1, Pages 136–147, September 2014.

2015

           Richard McClure, Daijiro Yanagisawa, Donald Stec, Dave Abdollahian, Dmitry Koktysh, Dritan Xhillari, Rudolph Jaeger, Gregg Stanwood, Eduard Chekmenev, Ikuo Tooyama, John C Gore, Wellington Pham. Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease. J Alzheimers Dis. 2015 ;44(1):283-95.

           Paul R. Houin, Livia A. Veress, Raymond C. Rancourt, Tara B. Hendry-Hofer, Joan E. Loader, Jacqueline S. Rioux, Rhonda B. Garlick and Carl W. White. Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatric Pulmonology, Volume 50, Issue 2, pages 118–126, February 2015.

           J. Kyle Bohannon, Matthew G. Lackemeyer, Jens H. Kuhn, Jiro Wada, Laura Bollinger, Peter B. Jahrling, and Reed F. Johnson. Generation and characterization of large-particle aerosols using a center flow tangential aerosol generator with a non-human-primate, head-only aerosol chamber. Inhalation Toxicology, (doi: 10.3109/08958378.2015.1033570).

           Paul M. Beringer, Timothy J. Bensman, Henry Ho, Melissa Agnello, Nicole Denovel, Albert Nguyen, Annie Wong-Beringer, Rosemary She, Dat Q. Tran, Samuel M. Moskowitz, and Michael E. Selsted. Rhesus u-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, October 3, 2015. DOI:10.1093/jac/dkv301.

           Carl W. White, Livia A. Veress. Treatment for Airway CAST Obstruction. National Jewish Health, November 12, 2015. United States Patent Application 20150322421.

2016

            Rasha Hammamieh, Seid Muhie, Richard Borschel, Aarti Gautam, Stacy-Ann Miller, Nabarun Chakraborty, Marti Jett. Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis. March 22, 2016 DOI: 10.1371/journal.pone.0151788.

            Donald J. Girouard Jr. and Mark A. Czarneski. Room, Suite Scale, Class III Biological Safety Cabinet, and Sensitive Equipment Decontamination and Validation Using Gaseous Chlorine Dioxide. Applied Biosafety, April 7, 2016. DOI: 10.1177/1535676016638750.

            John Lednicky, Maohua Pan, Julia Loeb, Hsin Hsieh, Arantzazu Eiguren-Fernandez, Susanne Hering, Z. Hugh Fan & Chang-Yu Wu. Highly efficient collection of infectious pandemic Influenza H1N1 virus (2009) through laminar-flow water based condensation. Aerosol Science and Technology, April 1, 2016 DOI:10.1080/02786826.2016.1179254.

            Selvakumar Subbian, Liana Tsenova, Jennifer Holloway, Blas Peixoto, Paul O'Brien, Véronique Dartois, Vikram Khetani, Jerome B. Zeldis, Gilla Kaplan. Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model. EBioMedicine, January 24, 2016 DOI: http://dx.doi.org/10.1016/j.ebiom.2016.01.015.

 

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