CH TECHNOLOGIES  |  PUBLICATIONS

Cigarette Smoke and E-cigarette Testing

2003

            E. L. Carmines, C. L. Gaworski, A. S. Faqi and N. Rajendran. In Utero Exposure to 1R4F Reference Cigarette Smoke: Evaluation of Developmental Toxicity. Toxicol. Sci. (2003) 75 (1): 134-147.

2004

           C. L. Gaworski, E. L. Carmines, A. S. Faqi and N. Rajendran. In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development. Toxicol. Sci. (2004) 79 (1): 157-169.

2005

           T. H. Thatcher, N. A. McHugh, R. W. Egan, R. W. Chapman, J. A. Hey, C. K. Turner, M. R. Redonnet, K. E. Seweryniak, P. J. Sime, and R. P. Phipps. The Role of CXCR2 in Cigarette Smoke-Induced Lung Inflammation. Am J Physiol Lung Cell Mol Physiol. Aug 2005; 289(2):

2006

           Sheung P. Ng, Allen E. Silverstone, Zhi-Wei Lai and Judith T. Zelikoff. Effects of Prenatal Exposure to Cigarette Smoke on Offspring Tumor Susceptibility and Associated Immune Mechanisms. Toxicol. Sci. (January 2006) 89 (1): 135-144.

           Aruna Kode, Se-Ran Yang and Irfan Rahman. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respiratory Research, 2006, Vol.7:132.

           Roger A. Renne, Hiroyuki Yoshimura, Kei Yoshino, George Lulham, Susumu Minamisawa, Albrecht Tribukait, Dennis D. Dietz, Kyeonghee Monica Lee and R. Bruce Westerberg. Effects of Flavoring and Casing Ingredients on the Toxicity of Mainstream Cigarette Smoke in Rats. Inhalation Toxicology, 2006, Vol. 18, No. 9, Pages 685-706.

2007

           Se-Ran Yang, Jessica Wright, Mark Bauter, Kathryn Seweryniak, Aruna Kode, Irfan Rahman. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. American Journal of Physiology - Lung Cellular and Molecular Physiology, February 2007, Vol. 292, no. L567-L576.

           Thomas H. Thatcher, Sanjay B. Maggirwar, Carolyn J. Baglole, Heather F. Lakatos, Thomas A. Gasiewicz, Richard P. Phipps, Patricia J. Sime. Aryl Hydrocarbon Receptor-Deficient Mice Develop Heightened Inflammatory Responses to Cigarette Smoke and Endotoxin Associated with Rapid Loss of the Nuclear Factor-κB Component RelB. The American Journal of Pathology, Volume 170, Issue 3, March 2007, Pages 855–864.

           Daniel F. Catanzaro, Ying Zhou, Rong Chen, Fangmin Yu, Sarah E. Catanzaro, Mariana S. De Lorenzo, Kotha Subbaramaiah, Xi Kathy Zhou, Domenico Pratico, Andrew J. Dannenberg, Babette B. Weksler. Potentially Reduced Exposure Cigarettes Accelerate Atherosclerosis: Evidence for the Role of Nicotine. Cardiovascular Toxicology, September 2007, Volume 7, Issue 3, pp 192-201.

           Christine Nadziejko, Kaije Fang, Antonio Bravo, and Terry Gordon. Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke. Journal of Applied Physiology, May 2007, vol. 102, no. 5, 1780-1785.

           Silvia S. Barbieri and Babette B. Weksler. Tobacco smoke cooperates with interleukin-1β to alter β-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo. The FASEB Journal, June 2007, vol. 21, no. 8:1831-1843.

           Ying Yan, Qing Tan, Yian Wang, Daolong Wang, Mike Jin, Terry Gordon, Ronald A. Lubet and Ming You. Enhanced Lung Tumor Development in Tobacco Smoke-Exposed p53 Transgenic and Kras2 Heterozygous Deficient Mice. Inhalation Toxicology, 2007, Vol. 19, No. s1, Pages 183-187.

            J. T. Hamm, S. Yee, N. Rajendran, R. L. Morrissey, S. J. Richter and M. Misra. Histological Alterations in Male A/J Mice Following Nose-Only Exposure to Tobacco Smoke. Inhalation Toxicology, 2007, Vol. 19, No. 5, Pages 405-418.

2008

           Se-Ran Yang, Samantha Valvo, Hongwei Yao, Aruna Kode, Saravanan Rajendrasozhan, Indika Edirisinghe, Samuel Caito, David Adenuga, Ryan Henry, George Fromm, Sanjay Maggirwar, Jian-Dong Li, Michael Bulger, and Irfan Rahman. IKKα Causes Chromatin Modification on Pro-Inflammatory Genes by Cigarette Smoke in Mouse Lung. Am J Respir Cell Mol Biol. Jun 2008; 38(6): 689–698.

           Thomas H. Thatcher, Randi P. Benson, Richard P. Phipps, and Patricia J. Sime. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. American Journal of Physiology - Lung Cellular and Molecular Physiology, Sep 2008; 295(3): L412-L421.

           Hongwei Yao, Indika Edirisinghe, Se-Ran Yang, Saravanan Rajendrasozhan, Aruna Kode, Samuel Caito, David Adenuga, Irfan Rahman. Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice. The American Journal of Pathology, Volume 172, Issue 5, May 2008, Pages 1222–1237.

           Hongwei Yao, Se-Ran Yang, Indika Edirisinghe, Saravanan Rajendrasozhan, Samuel Caito, David Adenuga, Michael A. O'Reilly, and Irfan Rahman. Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice. Am J Respir Cell Mol Biol. Jul 2008; 39(1): 7–18.

           Robert Fountaine, Ashley Milton, Tina Checchio, Greg Wei, Marilyn Stolar, John Teeter, Rudolph Jaeger and David Fryburg. Acute passive cigarette smoke exposure and inhaled human insulin (Exubera®) pharmacokinetics. British Journal of Clinical Pharmacology, Volume 65, Issue 6, pages 864–870, June 2008.

           Edward L. Carmines and Narayanan Rajendran. Evidence for Carbon Monoxide as the Major Factor Contributing to Lower Fetal Weights in Rats Exposed to Cigarette Smoke. Toxicol. Sci. (2008) 102 (2): 383-391.

           Indika Edirisinghe, Se-Ran Yang, Hongwei Yao, Saravanan Rajendrasozhan, Samuel Caito, David Adenuga, Chelsea Wong, Arshad Rahman, Richard P. Phipps, Zheng-Gen Jin and Irfan Rahman. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. The FASEB Journal, July 2008, vol. 22, no. 7:2297-2310.

            Oliver J. Harrisona, Joseph Foley, Brian J. Bolognese, Edward Long III, Patricia L. Podolin, Patrick T. Walsh. Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunology Letters, Volume 121, Issue 1, 16 November 2008, Pages 13–21.

           Hongwei Yao , Indika Edirisinghe , Saravanan Rajendrasozhan , Se-Ran Yang , Samuel Caito , David Adenuga , Irfan Rahman. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. American Journal of Physiology - Lung Cellular and Molecular Physiology, June 2008, Vol. 294, no. L1174-L1186.

           Sheung P. Ng and Judith T. Zelikoff. The Effects of Prenatal Exposure of Mice to Cigarette Smoke on Offspring Immune Parameters. Journal of Toxicology and Environmental Health, Part A: Current Issues, Volume 71, Issue 7, 2008.

           Charles L. Gaworski, Christopher R. E. Coggins and Edward L. Carmines. Palladium Alters Cigarette Smoke Toxicological Profile, but Accumulates in the Lungs of Rats During Inhalation Exposure. 2008, Vol. 20, No. 2, Pages 167-182.

2009

           Dae Jin Song, Myung Goo Min, [...], and David H. Broide. Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen. American Journal of Physiology - Lung Cellular and Molecular Physiology, Aug 2009; 297(2): L380-L387.

           Se-Ran Yang, Hongwei Yao, Saravanan Rajendrasozhan, Sangwoon Chung, Indika Edirisinghe, Samantha Valvo, George Fromm, Michael J. McCabe, Jr., Patricia J. Sime, Richard P. Phipps, Jian-Dong Li, Michael Bulger and Irfan Rahman. RelB Is Differentially Regulated by IκB Kinase-α in B Cells and Mouse Lung by Cigarette Smoke. Am J Respir Cell Mol Biol, Feb 2009, 40(2):147-158.

           John T. Bernert, Sydney M. Gordon, Ram B. Jain, Marielle C. Brinkman, Connie S. Sosnoff, Tiffany H. Seyler, Yang Xia, James E. McGuffey, David L. Ashley, James L. Pirkle, Eric J. Sampson. Increases in tobacco exposure biomarkers measured in non-smokers exposed to side stream cigarette smoke under controlled conditions. Biomarkers, March 2009, Vol. 14, No. 2, Pages 82-93.

           Michelle Natiello, George Kelly, James Lamca, David Zelmanovic, Richard W. Chapman, Jonathan E. Phillips. Manual and automated leukocyte differentiation in bronchoalveolar lavage fluids from rodent models of pulmonary inflammation. Comparative Clinical Pathology, May 2009, Volume 18, Issue 2, pp 101-111.

           Sheung P. Ng, Daniel J. Conklin, Aruni Bhatnagar, Duane D. Bolanowski, Jessica Lyon, and Judith T. Zelikoff. Prenatal Exposure to Cigarette Smoke Induces Diet- and Sex-Dependent Dyslipidemia and Weight Gain in Adult Murine Offspring. Environ Health Perspect. Jul 2009; 117(7): 1042–1048.

           Aris Polyzos, Thomas Ernst Schmid, Belem Piña-Guzmán, Betzabet Quintanilla-Vega, Francesco Marchetti. Differential sensitivity of male germ cells to mainstream and side stream tobacco smoke in the mouse. Toxicology and Applied Pharmacology, Volume 237, Issue 3, 15 June 2009, Pages 298–305.

           Terry Gordon, Maarten Bosland. Strain-dependent differences in susceptibility to lung cancer in inbred mice exposed to mainstream cigarette smoke. Cancer Letters, Volume 275, Issue 2, 18 March 2009, Pages 213–220.

           Elizabeth M. Vancza, Sheung Pui Ng, Jack R. Harkema, Judith T. Zelikoff. The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms. Journal of Immunotoxicology, June 2009, Vol. 6, No. 2, Pages 94-103.

2010

           Marina Miller, Alexa Pham, Jae Youn Cho, Peter Rosenthal, and David H. Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Am J Physiol Lung Cell Mol Physiol. Dec 2010; 299(6): L834–L842.

           Saravanan Rajendrasozhan, Sangwoon Chung, Isaac K. Sundar, Hongwei Yao, and Irfan Rahman. Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. American Journal of Physiology - Lung Cellular and Molecular Physiology, Feb 2010; 298(2): L197-L209.

           David Adenuga, Samuel Caito, Hongwei Yao, Isaac K. Sundar, Jae-Woong Hwang, Sangwoon Chung, Irfan Rahman. Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochemical and Biophysical Research Communications, Volume 403, Issues 3–4, 17 December 2010, Pages 452–456.

           Saravanan Rajendrasozhan, Jae-Woong Hwang, Hongwei Yao, Nandini Kishore, Irfan Rahman. Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulmonary Pharmacology & Therapeutics, Volume 23, Issue 3, June 2010, Pages 172–181.

           Gnanapragasam Arunachalam, Isaac K Sundar, Jae-woong Hwang, Hongwei Yao and Irfan Rahman. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. Journal of Inflammation 2010, 7:34 doi: 10.1186/1476-9255-7-34.

           Song D.J., Min M.G., Miller M., Cho J.Y., Yum H.Y., Broide D.H. Toll-Like Receptor-9 Agonist Inhibits Airway Inflammation, Remodeling and Hyperreactivity in Mice Exposed to Chronic Environmental Tobacco Smoke and Allergen. Int Arch Allergy Immunol, Vol. 151: 286-296, No. 4, 2010.

           Fernando M. Botelho, Gordon J. Gaschler, Sussan Kianpour, Cale C. J. Zavitz, Nancy J. Trimble, Jake K. Nikota, Carla M. T. Bauer, and Martin R. Stämpfli. Innate Immune Processes Are Sufficient for Driving Cigarette Smoke–Induced Inflammation in Mice. American Journal of Respiratory Cell and Molecular Biology, Vol. 42, No. 4 (2010), pp. 394-403.

           Hongwei Yao, Jae-woong Hwang, Jorge Moscat, Maria T. Diaz-Meco, Michael Leitges, Nandini Kishore, Xiong Li and Irfan Rahman. Protein Kinase Cζ Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications. The Journal of Biological Chemistry, 2010, 285, 5405-5416.

           Nicole J. Gentner, Lynn P. Weber. Using blood pressure telemetry to assess acute changes in arterial stiffness in rats after nitric oxide synthase inhibition or environmental tobacco smoke exposure. Canadian Journal of Physiology and Pharmacology, 2010, 88(9): 918-928.

           Jae-woong Hwang, Sangwoon Chung, Isaac K. Sundar, Hongwei Yao, Gnanapragasam Arunachalam, Michael W. McBurney, Irfan Rahman. Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD. Archives of Biochemistry and Biophysics, Volume 500, Issue 2, 15 August 2010, Pages 203–209.

           Sang Yeub Lee, Marina Miller, Jae Youn Cho, Dae Jin Song, Michael Karin, David H. Broide. Inactivation of IκB-kinase-β dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. International Immunopharmacology, Volume 10, Issue 8, August 2010, Pages 906–912.

           Gavin Pickett, Jeanclare Seagrave, Susan Boggs, Gregory Polzin, Patricia Richter, Yohannes Tesfaigzi. Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies. Toxicol Sci. 2010 Mar; 114(1):79-89.

           Sangwoon Chung, Isaac Kirubakaran Sundar, Hongwei Yao, Ye-Shih Ho, and Irfan Rahman. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of IκB kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol. Aug 2010; 299(2): L192–L203.

           Charleata Carter, Manoj Misra. Effects of Short-Term Cigarette Smoke Exposure on Fischer 344 Rats and on Selected Lung Proteins. Toxicol Pathol April 2010, vol. 38, no. 3:402-41.

           Isaac K. Sundar, Sangwoon Chung, Jae-Woong Hwang, Gnanapragasam Arunachalam, Suzanne Cook, Hongwei Yao, Witold Mazur, Vuokko L. Kinnula, Aron B. Fisher, and Irfan Rahman. Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury. Experimental Lung Research, October 2010, Vol. 36, No. 8, Pages 451-462.

           Charles L. Gaworski, Michael J. Oldham, Christopher R.E. Coggins. Toxicological considerations on the use of propylene glycol as a humectant in cigarettes. Toxicology, Volume 269, Issue 1, 28 February 2010, Pages 54–66.

           Samuel Caito, Saravanan Rajendrasozhan, Suzanne Cook, Sangwoon Chung, Hongwei Yao, Alan E. Friedman, Paul S. Brookes and Irfan Rahman. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. The FASEB Journal, September 2010, vol. 24 no. 9 3145-3159.

2011

           Sangwoon Chung, Isaac K. Sundar, Jae-Woong Hwang, Fiona E. Yull, Timothy S. Blackwell, Vuokko L. Kinnula, Michael Bulger, Hongwei Yao, Irfan Rahman. NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs. PLoS ONE, 2011, 6(8): e23488.doi:10.1371/journal.pone.0023488.

           Yanjun Wu, Charles J. Kotzer, Sokratis Makrogiannis, Gregory A. Logan, Hyking Haley, Mary S. Barnette, Susanta K. Sarkar. A Noninvasive [99mTc]DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD. Molecular Imaging and Biology, October 2011, Volume 13, Issue 5, pp 923-929.

           Lynn P. Webera, Ahmad Al-Dissia, Jordan S. Marit, Timothy N. German, Sharilyn D. Terletski. Role of carbon monoxide in impaired endothelial function mediated by acute second-hand tobacco, incense, and candle smoke exposures. Environmental Toxicology and Pharmacology, Volume 31, Issue 3, May 2011, Pages 453–459.

           Hongwei Yao, Irfan Rahman. Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vitro in Preclinical Models, and in Smokers and Patients with Airways Disease. Studies on Experimental Models, Oxidative Stress in Applied Basic Research and Clinical Practice, 2011, pp 399-420.

           David H. McMillan, Carolyn J. Baglole, Thomas H. Thatcher, Sanjay Maggirwar, Patricia J. Sime, Richard P. Phipps. Lung-Targeted Overexpression of the NF-κB Member RelB Inhibits Cigarette Smoke–Induced Inflammation. The American Journal of Pathology, Volume 179, Issue 1, July 2011, Pages 125–133.

           Jae-woong Hwang, Saravanan Rajendrasozhan, Hongwei Yao, Sangwoon Chung, Isaac K Sundar, Heidie L Huyck, Gloria S Pryhuber, Vuokko L Kinnula, Irfan Rahman. FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. Journal of Immunology, Jul 2011, vol. 187, no. 2:987-998.

           Silvia S. Barbieri, Patrizia Amadio, Sara Gianellini, Elena Zacchi, Babette B. Weksler and Elena Tremoli. Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase. The FASEB Journal, 2011, vol. 25 no. 10 3731-3740.

           Charles L. Gaworski, Michael J. Oldham, Karl A. Wagner, Christopher R.E. Coggins, George J. Patskan. An evaluation of the toxicity of 95 ingredients added individually to experimental cigarettes: approach and methods. Inhalation Toxicology, June 2011, Vol. 23, No. S1, Pages 1-12.

           Ahmad N. Al-Dissi, Lynn P. Weber. Resveratrol preserves cardiac function, but does not prevent endothelial dysfunction or pulmonary inflammation after environmental tobacco smoke exposure. Food and Chemical Toxicology, Volume 49, Issue 7, July 2011, Pages 1584–1591.

2012

           Isaac K. Sundar, Sangwoon Chung, Jae-woong Hwang, John D. Lapek Jr., Michael Bulger, Alan E. Friedman, Hongwei Yao, James R. Davie and Irfan Rahman. Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-κB-dependent Genes. PLoS ONE, 2012, 7(2): e31378. doi:10.1371/journal.pone.0031378.

           T. R. McAuley, P. K. Hopke, J. Zhao, S. Babaian. Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. October 2012, Vol. 24, No. 12, Pages 850-857.

2013

           Kexiong Lin, Shuanglin Liu, Yibo Shen, Qi Li. Berberine Attenuates Cigarette Smoke-Induced Acute Lung Inflammation. Inflammation, October 2013, Volume 36, Issue 5, pp 1079-1086.

           Patricia L. Podolin , Joseph P. Foley , Donald C. Carpenter , Brian J. Bolognese , Gregory A. Logan , Edward Long III, Oliver J. Harrison , Patrick T. Walsh. T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice. American Journal of Physiology - Lung Cellular and Molecular Physiology, March 2013, Vol. 304 no. L312-L323.

           Thomas H. Thatcher , Hsi-Min Hsiao , Elhanan Pinner , Moshe Laudon , Stephen J. Pollock , Patricia J. Sime, Richard P. Phipps. Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. American Journal of Physiology - Lung Cellular and Molecular Physiology, July 2013, Vol. 305no. L165-L174.

           Emma L. Beckett, Richard L. Stevens, Andrew G. Jarnicki, Richard Y. Kim, Irwan Hanish, Nicole G. Hansbro, Andrew Deane, Simon Keely, Jay C. Horvat, Ming Yang, MD, Brian G. Oliver, Nico van Rooijen, Mark D. Inman, Roberto Adachi, Roy J. Soberman, Sahar Hamadic, Peter A. Wark, Paul S. Foster, Philip M. Hansbro. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. Journal of Allergy and Clinical Immunology, Volume 131, Issue 3, March 2013, Pages 752–762.

           Vanitha Bhoopalan, Sung Gu Han, Mrudang M. Shah, David M. Thomas, Deepak K. Bhalla. Tobacco smoke modulates ozone-induced toxicity in rat lungs and central nervous system. Inhalation Toxicology, January 2013, Vol. 25, No. 1, Pages 21-28.

           Jill C Todt, Christine M Freeman, Jeanette P Brown, Joanne Sonstein, Theresa M Ames, Alexandra L McCubbrey, Fernando J Martinez, Stephen W Chensue, James M Beck and Jeffrey L Curtis. Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. Respiratory Research 2013, 14:33.

2014

           Carrie Yochum, Shannon Doherty-Lyon, Carol Hoffman, Muhammad M. Hossain, Judith T. Zelikoff, Jason R. Richardson. Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: Role of altered catecholamines and BDNF. Experimental Neurology, Volume 254, April 2014, Pages 145–152.

           Jae-Woong Hwang, Isaac K. Sundar, Hongwei Yao, Michael T. Sellix and Irfan Rahman. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. The FASEB Journal, 2014, vol. 28 no. 1 176-194.

           Isaac K. Sundar, Hongwei Yao, Yadi Huang, Elizabeth Lyda, Patricia J. Sime, Michael T. Sellix, Irfan Rahman. Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis. PLoS ONE 9(2): e87999, 2014.

           Amit A. Lugade, Paul N. Bogner, Thomas H. Thatcher, Patricia J. Sime, Richard P. Phipps and Yasmin Thanavala. Cigarette Smoke Exposure Exacerbates Lung Inflammation and Compromises Immunity to Bacterial Infection. The Journal of Immunology, Published April 21, 2014, doi:10.4049/jimmunol.1302584, 2014.

2015

           Dong-Fang Zhang, Jin Zhang, Ran Li. Salvianolic acid B attenuates lung inflammation induced by cigarette smoke in mice. European Journal of Pharmacology, doi:10.1016/j.ejphar.2015.05.003.

           Hitoshi Fujimoto, Hiroyuki Tsuji, Chigusa Okubo, Ichiro Fukuda, Tomoki Nishino, K. Monica Lee, Roger Renne, and Hiroyuki Yoshimura. Biological responses in rats exposed to mainstream smoke from a heated cigarette compared to a conventional reference cigarette. Inhal Toxicol, doi:10.3109/08958378.2015.1027799.

           Alan Chen-Yu Hsu, Malcolm R. Starkey, Irwan Hanish, Kristy Parsons, Tatt Jhong Haw, Linda J. Howland, Ian Barr, James B. Mahony, Paul S. Foster, Darryl A. Knight Peter A. Wark, and Philip M. Hansbro. Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, Vol. 191, No. 9 (2015), pp. 1012-1023.

           Swati Kumar, Tamar A. Smith-Norowitz, Stephan Kohlhoff, Petra Apfalter, Patricia Roblin, Andrei Kutlin, Jack Harkema, Sheung P. Ng, Shannon Doherty-Lyons, Judith T. Zelikoff, and Margaret R. Hammerschlag. Exposure to cigarette smoke and Chlamydia pneumoniae infection in mice: Effect on infectious burden, systemic dissemination and cytokine responses: A pilot study. Journal of Immunotoxicology, 2015, doi:10.3109/1547691X.2015.1006346.

           Diandian Li, Dan Xu, Tao Wang, Yongchun Shen, Shujin Guo, Xue Zhang, Lingli Guo, Xiaoou Li, Lian Liu, Fuqiang Wen. Silymarin Attenuates Airway Inflammation Induced by Cigarette Smoke in Mice. Inflammation, Volume 38, Issue 2, pp 871-878, April 2015.

           Hu JZ, Wang X, Feng J , Robertson BJ , Waters KM , Tilton SC , Pounds JG , Corley RA , Liu M and Hu M. Metabolite Signatures in Hydrophilic Extracts of Mouse Lungs Exposed to Cigarette Smoke Revealed by 1H NMR Metabolomics Investigation. Metabolomics 5: 143. doi:10.4172/2153-0769.1000143.

           Pooja Naik, Ravi K Sajja, Shikha Prasad, and Luca Cucullo. Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line. BMC Neuroscience 2015, 16:38 doi:10.1186/s12868-015-0173-3.

           Thomas E. Sussan, Sachin Gajghate, Rajesh K. Thimmulappa, Jinfang Ma, Jung-Hyun Kim, Kuladeep Sudini, Nicola Consolini, Stephania A. Cormier, Slawo Lomnicki, Farhana Hasan, Andrew Pekosz, Shyam Biswal. Exposure to Electronic Cigarettes Impairs Pulmonary Anti-Bacterial and Anti-Viral Defenses in a Mouse Model. February 4, 2015. DOI: 10.1371/journal.pone.0116861.

           Lingli Guo, Tao Wang, Yanqiu Wu, Zhicheng Yuan, Jiajia Dong, Xiao'ou Li, Jing An, Zenglin Liao, Xue Zhang, Dan Xu and Fu-Qiang Wen. WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway. Laboratory Investigation, August 31, 2015. DOI:10.1038/labinvest.2015.101.

2016

            Michael S. Werley, Dan J. Kirkpatrick, Michael J. Oldham, Ann M. Jerome, Timothy B. Langston, Patrick D. Lilly, Donna C. Smith, Willie J. Mckinney Jr. Toxicological Assessment of a Prototype E-cigaret Device and Three Flavor Formulations: a 90-day Inhalation Study in Rats. Inhalation Toxicology: International Forum for Respiratory Research, January 20, 2016 DOI:10.3109/08958378.2015.1130758.

            Anita R. Iskandar, Ignacio Gonzalez-Suarez, Shoaib Majeed, Diego Marescotti, Alain Sewer, Yang Xiang, Patrice Leroy, Emmanuel Guedj, Carole Mathis, Jean-Pierre Schaller, Patrick Vanscheeuwijck, Stefan Frentzel, Florian Martin, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng. A Framework for In Vitro Systems Toxicology Assessment of E-liquids. Toxicology Mechanisms and Methods, April 26, 2016 DOI:10.3109/15376516.2016.1170251.

            Gang Liu, Marion A. Cooley, Andrew G. Jarnicki, Alan C-Y. Hsu, Prema M. Nair, Tatt Jhong Haw, Michael Fricker, Shaan L. Gellatly, Richard Y. Kim, Mark D. Inman, Gavin Tjin, Peter A.B. Wark, Marjorie M. Walker, Jay C. Horvat, Brian G. Oliver, W. Scott Argraves, Darryl A. Knight, Janette K. Burgess, Philip M. Hansbro. Fibulin-1 Regulates the Pathogenesis of Tissue Remodeling in Respiratory Diseases. JCI Insight, June 16, 2016 DOI:10.1172/jci.insight.86380.

           Dana E. Lauterstein, Pamella B. Tijerina, Kevin Corbett, Betul Akgol Oksuz, Steven S. Shen, Terry Gordon, Catherine B. Klein, and Judith T. Zelikoff. Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages. International Journal of Environmental Research and Public Health, April 2016, DOI: 10.3390/ijerph13040417.

            Jiayuan Zhao, Georgios Pyrgiotakis & Philip Demokritou. Development and characterization of electronic-cigarette exposure generation system (Ecig-EGS) for the physico-chemical and toxicological assessment of electronic cigarette emissions. Inhalation Toxicology, November 10, 2016 DOI:10.1080/08958378.2016.1246628.

           Chad A. Lerner, Wei Lei, Isaac K. Sundar, and Irfan Rahman. Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury. Front Pharmacol., October 2016 DOI:10.3389/fphar.2016.00391

 

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