Nose-Only Chambers (ONARES) and Animal Restraints


           George J. Jakab and David R. Hemenway. Concomitant exposure to carbon black particulates enhances ozone‐induced lung inflammation and suppression of alveolar macrophage phagocytosis. Journal of Toxicology and Environmental Health, Volume 41, Issue 2, 1994.

           Matthew W. Himmelstein, Max J. Turner, Bahman Asgharian and James A. Bond. Comparison of blood concentrations of 1, 3-butadiene and butadiene epoxides in mice and rats exposed to 1, 3-butadiene by inhalation. Carcinogenesis (1994) 15 (8): 1479-1486.


           K. D. Thrall and D. V. Kenny. Evaluation of a Carbon Tetrachloride Physiologically Based Pharmacokinetic Model Using Real-Time Breath-Analysis Monitoring of the Rat. Inhalation Toxicology, 1996, Vol. 8, No. 3, Pages 251-261.

           James M. Mathews, James H. Raymer, George R. Velez, C. Edwin Garner and John R. Bucher. The influence of cytochrome P450 enzyme activity on the composition and quantity of volatile organics in expired breath. Biomarkers, 1996, Vol. 1, No. 3, Pages 196-201.

           K. D. Thrall and D. V. Kenny. Evaluation of a Carbon Tetrachloride Physiologically Based Pharmacokinetic Model Using Real-Time Breath-Analysis Monitoring of the Rat. Inhalation Toxicology, 1996, Vol. 8, No. 3, Pages 251-261.

           James M. Mathews, James H. Raymer, George R. Velez, C. Edwin Garner and John R. Bucher. The influence of cytochrome P450 enzyme activity on the composition and quantity of volatile organics in expired breath. Biomarkers, 1996, Vol. 1, No. 3, Pages 196-201.


           R. Vincent, S. G. Bjarnason, I. Y. Adamson, C. Hedgecock, P. Kumarathasan, J. Guénette, M. Potvin, P. Goegan, and L. Bouthillier. Acute pulmonary toxicity of urban particulate matter and ozone. Am J Pathol. Dec 1997; 151(6): 1563–1570.

           John B. Morris. Uptake of Acetaldehyde Vapor and Aldehyde Dehydrogenase Levels in the Upper Respiratory Tracts of the Mouse, Rat, Hamster, and Guinea Pig. Fundamental and Applied Toxicology, Volume 35, Issue 1, January 1997, Pages 91–100.

           Mitchell D. Cohen, Susanne Becker, Robert Devlin, Richard B. Schlesinger and Judith T. Zelikoff. Effects of Vanadium Upon Pol Yi:C-Induced Responses in Rat Lung and Alveolar Macrophages. Journal of Toxicology and Environmental Health, Volume 51, Issue 6, 1997.

           Josee Guenette, Sairin Hayes, and Renaud Vincent. Stable Gaseous Atmospheres for Nose-Only Inhalation Using Mass Flow Controllers. 1997, Vol. 7, No. 2, Pages 77-89.

           Mitchell D. Cohen Judith T. Zelikoff Lung-Chi Chen Richard B. Schlesinger. Pulmonary Retention and Distribution of Inhaled Chromium: Effects of Particle Solubility and Coexposure to Ozone. Inhalation Toxicology, 1997, Vol. 9, No. 9, Pages 843-866.


           Léo Bouthillier, Renaud Vincent, Patrick Goegan, Ian Y.R. Adamson, Stephen Bjarnason, Mark Stewart, Josée Guénette, Marc Potvin, Prem Kumarathasan. Acute Effects of Inhaled Urban Particles and Ozone: Lung Morphology, Macrophage Activity, and Plasma Endothelin-1. The American Journal of Pathology, Volume 153, Issue 6, December 1998, Pages 1873–1884.

           Terry Gordon, Christine Nadziejko, Richard Schlesinger, Lung Chi Chen. Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats. Toxicology Letters, Volumes 96–97, 1 August 1998, Pages 285–288.

           John B. Morris. Effect of Acrolein Vapor Upper Respiratory Tract Uptake of Acetaldehyde. Inhalation Toxicology, 1998, Vol. 10, No. 9, Pages 843-856.


           Terry Gordon. A Centrifugal Particle Concentrator for Use in Inhalation Toxicology. Inhalation Toxicology, 1999, Vol. 11, No. 1, Pages 71-87.

           Albert F. Gunnison, Gary E. Hatch. O3-induced inflammation in prepregnant, pregnant, and lactating rats correlates with O3 dose estimated by18O. American Journal of Physiology - Lung Cellular and Molecular Physiology, February 1999, Vol. 276, no. L332-L340.

           John B. Morris, John Stanek, and Gerald Gianutsos. Sensory nerve-mediated immediate nasal responses to inspired acrolein. Journal of Applied Physiology November 1, 1999 vol. 87 no. 5 1877-1886.

           John B. Morris. A Method for Measuring Upper Respiratory Tract Vapor Uptake and its Applicability to Quantitative Inhalation Risk Assessment. Inhalation Toxicology, 1999, Vol. 11, No. 10, Pages 943-965.


           E. J. Ruijgrok, A. G. Vulto and E. W. M. Van Etten. Aerosol Delivery of Amphotericin B Desoxycholate (Fungizone) and Liposomal Amphotericin B (AmBisome): Aerosol Characteristics and In-vivo Amphotericin B Deposition in Rats. Journal of Pharmacy and Pharmacology, June 2000, Volume 52, Issue 6, pages 619–627.

           Karla D. Thrall, Torka S. Poet.Determination of Biokinetic Interactions in Chemical Mixtures Using Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling. Journal of Toxicology and Environmental Health, Part A: Current Issues, Volume 59, Issue 8, 2000.

           John B. Morris. Uptake of Styrene in the Upper Respiratory Tract of the CD Mouse and Sprague-Dawley Rat. Toxicol. Sci. (2000) 54 (1): 222-228.

           R. T. Henrich, W. D. Johnson, N. Rajendran, R. I. Freudenthal, M. J. Tomlinson, C. Aranyi. Twenty-Eight Day Nose-Only Inhalation Toxicity Study of Resorcinol Bis-Diphenylphosphate (Fyrolflex RDP) in Rats. International Journal of Toxicology July 2000 vol. 19 no. 4 223-231.


           J. Stanek, P. T. Symanowicz, J. E. Olsen, G. Gianutsos, J. B. Morris. Sensory-Nerve-Mediated Nasal Vasodilatory Response to Inspired Acetaldehyde and Acetic Acid Vapors. Inhalation Toxicology, 2001, Vol. 13, No. 9, Pages 807-822.

           Elisabeth J. Ruijgrok, Arnold G. Vultob and Els W. M. Van Etten. Efficacy of aerosolized amphotericin B desoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats. J. Antimicrob. Chemother. (2001) 48 (1): 89-95.


           Deepak K. Bhalla, Paul G. Reinhart, Cheng Bai and Suresh K. Gupta. Amelioration of Ozone-Induced Lung Injury by Anti-Tumor Necrosis Factor-α.. Toxicol. Sci. (2002) 69 (2): 400-408.

           Christine Nadziejko, Kaijie Fang, Elizabeth Nadziejko, Sandy Pais Narciso, Mianhua Zhong, Lung Chi Chen. Immediate effects of particulate air pollutants on heart rate and respiratory rate in hypertensive rats. Cardiovascular Toxicology, December 2002, Volume 2, Issue 4, pp 245-252.

           John B. Morris. Sensory Nerve-Mediated Nasal Vasodilatory Response to Inspired Ethyl Acrylate. Inhalation Toxicology, 2002, Vol. 14, No. 6, Pages 585-597.

           Laurence D. Fechter, David L. Johnson, Robert A. Lynch. The Relationship of Particle Size to Olfactory Nerve Uptake of a Non-Soluble Form of Manganese Into Brain. NeuroToxicology, Volume 23, Issue 2, July 2002, Pages 177–183.

           Dr. Prem Kumarathasan, Renaud Vincent, Patrick Goegan, Stephen Bjarnason and Josée Guénette. Alteration in Aromatic Hydroxylation and Lipids Oxidation Status in the Lungs of Rats Exposed to Ozone. Toxicology Mechanisms and Methods, 2002, Vol. 12, No. 3, Pages 195-210.


           Michael DeLorme, Xiufeng Gao, Nicole Doyon-Reale, Holly Barraclough-Mitchell and David Bassett. Inflammatory Effects of Inhaled Endotoxin-Contaminated Metal Working Fluid Aerosols in Rats. Journal of Toxicology and Environmental Health, Part A: Current Issues, Volume 66, Issue 1, 2003.

           Xue-Jun Yin, Rosana Schafer, Jane Y C Ma, James M Antonini, Jenny R Roberts, David N Weissman, Paul D Siegel, and Joseph K H Ma. Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats. Environ Health Perspect. Apr 2003; 111(4): 524–530.

           Bahman Asgharian, James T. Kelly and Earl W. Tewksbury. Respiratory Deposition and Inhalability of Monodisperse Aerosols in Long-Evans Rats. Toxicol. Sci. (2003) 71 (1): 104-111.

           E. L. Carmines, C. L. Gaworski, A. S. Faqi and N. Rajendran. In Utero Exposure to 1R4F Reference Cigarette Smoke: Evaluation of Developmental Toxicity. Toxicol. Sci. (2003) 75 (1): 134-147.


           Charles A. Scanga, Andre Bafica, Carl G. Feng, Allen W. Cheever, Sara Hieny and Alan Sher. MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression. Infect. Immun. April 2004 vol. 72 no. 4 2400-2404.

           Xing-Dong Zhang, Jeffrey S Fedan, Daniel M Lewis, Paul D Siegel. Asthmalike biphasic airway responses in Brown Norway rats sensitized by dermal exposure to dry trimellitic anhydride powder. Journal of Allergy and Clinical Immunology, Volume 113, Issue 2, February 2004, Pages 320–326.

           Xuejun J. Yin, Caroline C. Dong, Jane Y. C. Ma, James M. Antonini, Jenny R. Roberts, Charles F. Stanley, Rosana Schafer and Joseph K. H. Ma. Suppression of Cell-Mediated Immune Responses to Listeria Infection by Repeated Exposure to Diesel Exhaust Particles in Brown Norway Rats. Toxicol. Sci. (2004) 77 (2): 263-271.

           C. L. Gaworski, E. L. Carmines, A. S. Faqi and N. Rajendran. In Utero and Lactation Exposure of Rats to 1R4F Reference Cigarette Mainstream Smoke: Effect on Prenatal and Postnatal Development. Toxicol. Sci. (2004) 79 (1): 157-169.

Charles A. Scanga, Andre Bafica, Carl G. Feng, Allen W. Cheever, Sara Hieny, and Alan Sher. MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression. Infection and Immunity, Apr. 2004, Vol. 72, No. 4, p. 2400-2404.

           Sambhu N. Bhattacharyya, Michael A. Dubick, Loudon D. Yantis, John I. Enriquez, Kelvin C. Buchanan, Surinder K. Batra, Rebecca A. Smiley. In Vivo Effect of Wood Smoke on the Expression of Two Mucin Genes in Rat Airways. Inflammation, April 2004, Volume 28, Issue 2, pp 67-76.

           Pilar Domenech, Michael B. Reed, Cynthia S. Dowd, Claudia Manca, Gilla Kaplan and Clifton E. Barry III. The Role of MmpL8 in Sulfatide Biogenesis and Virulence of Mycobacterium tuberculosis. The Journal of Biological Chemistry, Vol. 279, No. 20, 2004, pp. 21257–21265.

           Alison K. Pickering, Manuel Osorio, Gloria M. Lee, Vanessa K. Grippe, Mechelle Bray and Tod J. Merkel. Cytokine Response to Infection with Bacillus anthracis Spores. Infect. Immun. November 2004 vol. 72 no. 11 6382-6389.

           Christine Nadziejko, Kaijie Fang, Sandy Narciso, Minhua Zhong, Wei Cheng Su, Terry Gordon, Arthur Nádas and Lung Chi Chen. Effect of Particulate and Gaseous Pollutants on Spontaneous Arrhythmias in Aged Rats. Inhalation Toxicology, 2004, Vol. 16, No. 6-7, Pages 373-380.


           Eric T. Harvill, Gloria Lee, Vanessa K. Grippe and Tod J. Merkel. Complement Depletion Renders C57BL/6 Mice Sensitive to the Bacillus anthracis Sterne Strain. Infect. Immun. July 2005 vol. 73 no. 7 4420-4422.

           Molly A. Hughes, Candace S. Green, Lisa Lowchyj, Gloria M. Lee, Vanessa K. Grippe, Michael F. Smith Jr., Li-Yun Huang, Eric T. Harvill and Tod J. Merkel. MyD88-Dependent Signaling Contributes to Protection following Bacillus anthracis Spore Challenge of Mice: Implications for Toll-Like Receptor Signaling. Infect. Immun. November 2005 vol. 73 no. 11 7535-7540.

           Caroline C. Dong, Xuejun J. Yin, Jane Y. C. Ma, Lyndell Millecchia, Zhong-Xin Wu, Mark W. Barger, Jenny R. Roberts, James M. Antonini, Richard D. Dey and Joseph K. H. Ma. Effect of Diesel Exhaust Particles on Allergic Reactions and Airway Responsiveness in Ovalbumin-Sensitized Brown Norway Rats. Toxicol. Sci. (November 2005) 88 (1): 202-212.

           Xuejun J. Yin, Caroline C. Dong, Jane Y. C. Ma, James M. Antonini, Jenny R. Roberts, Mark W. Barger and Joseph K. H. Ma. Sustained Effect of Inhaled Diesel Exhaust Particles on T-Lymphocyte–Mediated Immune Responses Against Listeria monocytogenes. Toxicol. Sci. (November 2005) 88 (1): 73-81.

           Caroline C. Dong, Xuejun J. Yin, Jane Y. C. Ma, Lyndell Millecchia, Mark W. Barger, Jenny R. Roberts, Xing-Dong Zhang, James M. Antonini and Joseph K. H. Ma. Exposure of Brown Norway Rats to Diesel Exhaust Particles Prior to Ovalbumin (OVA) Sensitization Elicits IgE Adjuvant Activity but Attenuates OVA-Induced Airway Inflammation. Toxicol. Sci. (November 2005) 88 (1): 150-160.

           Annette Robichaud, Stephanie A. Tuck, Stacia Kargman, John Tam, Elizabeth Wong, Mark Abramovitz, James Mortimer, Helen E. Burston, Paul Masson, Jeremy Hirota, Deborah Slipetz, Brian Kennedy, Gary O'Neill, and Steven Xanthoudakis. Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma. American Journal of Respiratory Cell and Molecular Biology, Vol. 33, No. 3 (2005), pp. 303-314.

           Elisabeth J. Ruijgrok, Marcel H. A. Fens, Irma A. J. M. Bakker-Woudenberg, Els W. M. Van Etten, Elisabeth J. Ruijgrok and Arnold G. Vulto. Nebulization of four commercially available amphotericin B formulations in persistently granulocytopenic rats with invasive pulmonary aspergillosis: evidence for long-term biological activity. Journal of Pharmacy and Pharmacology, Volume 57, Issue 10, pages 1289–1295, October 2005.

           Gordon L. Kindlmann, David M. Weinstein, Greg M. Jones, Christopher R. Johnson, Mario R. Capecchi, Charles Keller. Practical Vessel Imaging by Computed Tomography in Live Transgenic Mouse Models for Human Tumors. Molecular Imaging. Oct. 2005, Vol. 4 Issue 4, p417-424.

           Chuen-Chau Chang, Jing-Shiang Hwang, Chang-Chuan Chan, Peng-Yau Wang, Tsuey-Hwa Hu and Tsun-Jen Cheng. Effects of Concentrated Ambient Particles on Heart Rate Variability in Spontaneously Hypertensive Rats. J Occup Health 2005; 47: 471–480.


           Ryan P. Vaughan, Michael T. Szewczyk Jr, Michael J. Lanosa, Christopher R. DeSesa, Gerald Gianutsos and John B. Morris. Adenosine Sensory Transduction Pathways Contribute to Activation of the Sensory Irritation Response to Inspired Irritant Vapors. Toxicol. Sci. (October 2006) 93 (2): 411-421.

           Suniket V. Fulzele, Abhijit Chatterjee, Madhu Sudhan Shaik, Tanise Jackson, Mandip Singh. Inhalation Delivery and Anti-tumor Activity of Celecoxib in Human Orthotopic Non-Small Cell Lung Cancer Xenograft Model. Pharmaceutical Research, September 2006, Volume 23, Issue 9, pp 2094-2106.

           Xing-Dong Zhang, Michael E. Andrew, Ann F. Hubbs and Paul D. Siegel. Airway Responses in Brown Norway Rats Following Inhalation Sensitization and Challenge with Trimellitic Anhydride. Toxicol. Sci. (2006) 94 (2): 322-329.

           C.M. Schramm, L. Guernsey, E. Secor, R.S. Thrall. Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1762, Issue 5, May 2006, Pages 499–501.

           Prakash M. Kabbur, William F. Carson IV, Linda Guernsey, Eric R. Secor Jr., Roger S. Thrall. Craig M. Schramm. Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease. Cellular Immunology, Volume 239, Issue 1, January 2006, Pages 67–74.

           Liana Tsenova, Ryhor Harbacheuski, Evette Ellison, Claudia Manca, and Gilla Kaplan. Aerosol Exposure System for Rabbits: Application to M. Tuberculosis Infection. Applied Biosafety, 2006, 11 (1) pp. 7-14.

           Patrick J. Sabourin, Jennifer A. Price, Stacy L. Casbohm, Mark R. Perry, Richard S. Tuttle, James V. Rogers, Kimberly S. Rowell, James E. Estep and Carol L. Sabourin. Evaluation of Acute Immunotoxicity of Aerosolized Aflatoxin B1 in Female C57BL/6N Mice. Journal of Immunotoxicology, 2006, Vol. 3, No. 1, Pages 11-20.


           Crystal L. Loving, Mary Kennett, Gloria M. Lee, Vanessa K. Grippe and Tod J. Merkel. Murine Aerosol Challenge Model of Anthrax. Infect. Immun. June 2007 vol. 75 no. 6 2689-2698.

           Daniel F. Catanzaro, Ying Zhou, Rong Chen, Fangmin Yu, Sarah E. Catanzaro, Mariana S. De Lorenzo, Kotha Subbaramaiah, Xi Kathy Zhou, Domenico Pratico, Andrew J. Dannenberg, Babette B. Weksler. Potentially Reduced Exposure Cigarettes Accelerate Atherosclerosis: Evidence for the Role of Nicotine. Cardiovascular Toxicology, September 2007, Volume 7, Issue 3, pp 192-201.

           Chuen-Chau Chang, Jing-Shiang Hwang, Chang-Chuan Chan, Peng-Yau Wang and Tsun-Jen Cheng. Concentrated Ambient Particles on Heart Rate, Blood Pressure, and Cardiac Contractility in Spontaneously Hypertensive Rats During a Dust Storm Event. Inhalation Toxicology, 2007, Vol. 19, No. 11, Pages 973-978.

           Richard W. Chapman, Aileen House, Howard Jones, Jennifer Richard, Chander Celly, Dan Prelusky, Pauline Ting, John C. Hunter, James Lamca, Jonathan E. Phillips. Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats. European Journal of Pharmacology, Volume 571, Issues 2–3, 1 October 2007, Pages 215–221.

           Lida Mohtasham, Alexander Auais and Giovanni Piedimonte. Nerve growth factor mediates steroid-resistant inflammation in respiratory syncytial virus infection. Pediatric Pulmonology, Volume 42, Issue 6, pages 496–504, June 2007.

           Paula J. Brunton, Matthias Sausbier, Georg Wietzorrek, Ulrike Sausbier, Hans-Guenther Knaus, John A. Russell, Peter Ruth, and Michael J. Shipston. Hypothalamic-Pituitary-Adrenal Axis Hyporesponsiveness to Restraint Stress in Mice Deficient for Large-Conductance Calcium- and Voltage-Activated Potassium (BK) Channels. Endocrinology, Volume 148 Issue 11 | November 1, 2007.

           Dennis M. Klinman, Debra Currie, Gloria Lee, Vanessa Grippe and Tod Merkel. Systemic but not mucosal immunity induced by AVA prevents inhalational anthrax. Microbes and Infection, Volume 9, Issues 12–13, October 2007, Pages 1478–1483.

           Silvia S. Barbieri and Babette B. Weksler. Tobacco smoke cooperates with interleukin-1β to alter β-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo. The FASEB Journal, June 2007, vol. 21, no. 8:1831-1843.

           J. T. Hamm, S. Yee, N. Rajendran, R. L. Morrissey, S. J. Richter and M. Misra. Histological Alterations in Male A/J Mice Following Nose-Only Exposure to Tobacco Smoke. Inhalation Toxicology, 2007, Vol. 19, No. 5, Pages 405-418.


           Eric R. Secor Jr, William F. Carson IV, Anurag Singh, Mellisa Pensa, Linda A. Guernsey, Craig M. Schramm, and Roger S. Thrall. Oral Bromelain Attenuates Inflammation in an Ovalbumin-Induced Murine Model of Asthma. Evidence-Based Complementary and Alternative Medicine, Volume 5 (2008), Issue 1, Pages 61-69.

           Anurag Singh, Roger S Thrall, Linda A Guernsey, William F Carson IV, Eric R Secor Jr, Robert E Cone, Thiruchandurai V Rajan and Craig M Schramm. Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model. Immunology and Cell Biology (2008) 86, 535–538, May 2008.

           P. Meers, M. Neville, V. Malinin, A. W. Scotto, G. Sardaryan, R. Kurumunda, C. Mackinson, G. James, S. Fisher and W. R. Perkins. Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. J. Antimicrob. Chemother. (2008) 61 (4): 859-868.

           Carol A. Wu, John J. Peluso, John D. Shanley, Lynn Puddington, Roger S. Thrall. Murine Cytomegalovirus Influences Foxj1 Expression, Ciliogenesis, and Mucus Plugging in Mice with Allergic Airway Disease. The American Journal of Pathology, Volume 172, Issue 3, March 2008, Pages 714–724.

           Edward L. Carmines and Narayanan Rajendran. Evidence for Carbon Monoxide as the Major Factor Contributing to Lower Fetal Weights in Rats Exposed to Cigarette Smoke. Toxicol. Sci. (2008) 102 (2): 383-391.

           Peter W. Stengel, Douglas J. Zeckner, Wen-Kai Kevin Guo, Jeffrey A. Wolos, David W. Snyder. Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: Effect of inhaled budesonide and ciglitazone. European Journal of Pharmacology, Volume 578, Issue 1, 6 January 2008, Pages 65–75.

           Oliver J. Harrisona, Joseph Foley, Brian J. Bolognese, Edward Long III, Patricia L. Podolin, Patrick T. Walsh. Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunology Letters, Volume 121, Issue 1, 16 November 2008, Pages 13–21.


           Crystal L. Loving, Taruna Khurana, Manuel Osorio, Gloria M. Lee, Vanessa K. Kelly, Scott Stibitz and Tod J. Merkel. Role of Anthrax Toxins in Dissemination, Disease Progression, and Induction of Protective Adaptive Immunity in the Mouse Aerosol Challenge Model. Infect. Immun. January 2009 vol. 77 no. 1 255-265.

           Crystal L. Loving, Manuel Osorio, Yun-Gi Kim, Gabriel Nuñez, Molly A. Hughes and Tod J. Merkel. Nod1/Nod2-Mediated Recognition Plays a Critical Role in Induction of Adaptive Immunity to Anthrax after Aerosol Exposure. Infect. Immun., October 2009, vol. 77, no. 10, 4529-4537.

           D. Saini, R. M. Buller, A. S. Biris and P. Biswas. Characterization of a Nose-Only Inhalation Exposure System for Ectromelia Virus Infection of Mice. Particulate Science and Technology: An International Journal, Volume 27, Issue 2, 2009, p.152-165.

           Matthew J. Panzner, Khadijah M. Hindi, Brian D. Wright, Jane B. Taylor, Daniel S. Han, Wiley J. Youngs and Carolyn L. Cannon. A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens. Dalton Transactions, Issue 35: 7308-7313, 2009.

           Shanshan Cai, Rachel L. Zemans, Scott K. Young, G. Scott Worthen, and Samithamby Jeyaseelan. Myeloid Differentiation Protein-2–Dependent and –Independent Neutrophil Accumulation during Escherichia coli Pneumonia. Am J Respir Cell Mol Biol. Jun 2009; 40(6): 701–709.

           Khadijah M. Hindia, Andrew J. Dittob, Matthew J. Panznera, Douglas A. Medvetza, Daniel S. Hanc, Christine E. Hovisc, Julia K. Hilliardc, Jane B. Taylorc, Yang H. Yunb, Carolyn L. Cannonc, Wiley J. Youngsa. The antimicrobial efficacy of sustained release silver–carbene complex-loaded l-tyrosine polyphosphate nanoparticles: Characterization, in vitro and in vivo studies. Biomaterials, Volume 30, Issue 22, August 2009, Pages 3771–3779.

           Jorrit J Hofstra, Alexander D Cornet, Bart F de Rooy, Alexander P Vlaar, Tom van der Poll, Marcel Levi, Sebastian AJ Zaat and Marcus J Schultz. Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumonia in rats. Critical Care, 2009, 13:R145.

           John Doukas, Lisa Eide, Karin Stebbins, Adrienne Racanelli-Layton, Luis Dellamary, Michael Martin, Elena Dneprovskaia, Glenn Noronha, Richard Soll, Wolfgang Wrasidlo, Lisette M. Acevedo and David A. Cheresh. Aerosolized Phosphoinositide 3-Kinase γ/δ Inhibitor TG100-115 [3-[2, 4-Diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a Therapeutic Candidate for Asthma and Chronic Obstructive Pulmonary Disease. The Journal of Pharmacology and Experimental Therapeutics, March 2009, vol. 328, no. 3:758-765.

           Marco Zaru, Chiara Sinico, Alessandro De Logu, Carla Caddeo, Francesco Lai, Maria Letizia Manca, Anna Maria Fadda. Rifampicin-loaded liposomes for the passive targeting to alveolar macrophages: in vitro and in vivo evaluation. Journal of Liposome Research, March 2009, Vol. 19, No. 1, Pages 68-76.

           Manuel Osorio, Yanping Wu, Sunil Singh, Tod J. Merkel, Siba Bhattacharyya, Milan S. Blake and Dennis J. Kopecko. Anthrax Protective Antigen Delivered by Salmonella enterica Serovar Typhi Ty21a Protects Mice from a Lethal Anthrax Spore Challenge. Infect. Immun. April 2009 vol. 77 no. 4 1475-1482.

           John Doukas, Lisa Eide, Karin Stebbins, Adrienne Racanelli-Layton, Luis Dellamary, Michael Martin, Elena Dneprovskaia, Glenn Noronha, Richard Soll, Wolfgang Wrasidlo, Lisette M. Acevedo, David A. Cheresh. Aerosolized Phosphoinositide 3-Kinase γ/δ Inhibitor TG100-115 as a Therapeutic Candidate for Asthma and Chronic Obstructive Pulmonary Disease. Journal of Pharmacology and Experimental Therapeutics, 2009, Vol. 328, No. 3:758-765.

           Brian K. Heimbuch, Brenton R. Stone, Rashelle S. McDonald, Kimberly R. Kinney, April E. Lumley, Joseph D Wander. Assaying Benefits of Poly[styrene-4-(trimethylammonium)methyl Triiodide] in Respiratory Protection Devices. 2009 - DTIC Document,


           Marina Miller, Alexa Pham, Jae Youn Cho, Peter Rosenthal, and David H.Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Am J Physiol Lung Cell Mol Physiol. Dec 2010; 299(6): L834–L842.

           Heidi C. O'Neill, Carl W. White, Livia A. Veress, Tara B. Hendry-Hofer, Joan E. Loader, Elysia Min, Jie Huang, Raymond C. Rancourt, Brian J. Day. Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide. Free Radical Biology and Medicine, Volume 48, Issue 9, 1 May 2010, Pages 1188–1196.

           Laurence D. Fechter, Caroline A. Gearhart and Sherry Fulton. Ototoxic Potential of JP-8 and a Fischer-Tropsch Synthetic Jet Fuel following Subacute Inhalation Exposure in Rats. Toxicol. Sci. (2010) 116 (1): 239-248.

           Richard S Tuttle, William A Sosna, Deirdre E Daniels, Sara B Hamilton and John A Lednicky. Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferrets. Virology Journal 2010, 7:135.

           Raphael T. Tremblay, Sheppard A. Martin, Jeffrey W. Fisher. Novel characterization of the aerosol and gas-phase composition of aerosolized jet fuel. Novel characterization of the aerosol and gas-phase composition of aerosolized jet fuel.

           John A Lednicky, Sara B Hamilton, Richard S Tuttle, William A Sosna, Deirdre E Daniels, David E Swayne. Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1). Virology Journal 2010, 7:231.

           Jorrit J. Hofstra, Alexander P. Vlaar, Alexander D. Cornet, Barry Dixon, Joris J. Roelofs, Goda Choi, Tom van der Poll, Marcel Levi, and Marcus J. Schultz. Nebulized Anticoagulants Limit Pulmonary Coagulopathy, But Not Inflammation, in a Model of Experimental Lung Injury. Journal of Aerosol Medicine and Pulmonary Drug Delivery, April 2010, 23(2): 105-111.

           David Bassett, Fusao Hirata, Xiufeng Gao, Rangaramanujam Kannan, Janet Kerr, Nicole Doyon-Reale, Susan Wilson and Mary Lieh-Lai. Reversal of Methylprednisolone Effects in Allergen-Exposed Female Balb/c Mice. Journal of Toxicology and Environmental Health, Part A: Current Issues, Volume 73, Issue 11, 2010.

           Lisa A. Morici, Julie Heang, Tim Tate, Peter J. Didier, Chad J. Roy. Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection. Microbial Pathogenesis, Volume 48, Issue 1, January 2010, Pages 9–17.

           Esra Mutlu, Leonard B. Collins, Matthew D. Stout, Patricia B. Upton, Laura R. Daye, Darrell Winsett, Gary Hatch, Paul Evansky, and James A. Swenberg. Development and Application of an LC-MS/MS Method for the Detection of the Vinyl Chloride-Induced DNA Adduct N2, 3-Ethenoguanine in Tissues of Adult and Weanling Rats Following Exposure to [13C2]-VC. Chem. Res. Toxicol., 2010, 23 (9), pp 1485–1491.

           Olga B. Garbuzenko, Maha Saad, Vitaly P. Pozharov, Kenneth R. Reuhl, Gediminas Mainelis and Tamara Minko. Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance. PNAS, June 8, 2010, vol. 107,| no. 23: 10737–10742.


           Yanjun Wu, Charles J. Kotzer, Sokratis Makrogiannis, Gregory A. Logan, Hyking Haley, Mary S. Barnette, Susanta K. Sarkar. A Noninvasive [99mTc] DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD. Molecular Imaging and Biology, October 2011, Volume 13, Issue 5, pp 923-929.

           Kerstin J. Williams, Helena I. Boshoff, Nitya Krishnan, Jacqueline Gonzales, Dirk Schnappinger, Brian D. Robertson. The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo. Tuberculosis, Volume 91, Issue 6, November 2011, Pages 549–555.

           De-Peng Jiang, Qi Li, Jie Yang, Juliy M. Perelman, Victor P. Kolosov, Xiang-Dong Zhou. Scutellarin Attenuates Human-Neutrophil-Elastase-Induced Mucus Production by Inhibiting the PKC-ERK Signaling Pathway in Vitro and in Vivo. The American Journal of Chinese Medicine, January 2011, Vol. 39, No. 6: pp. 1193-1206.

           Douglas S. Reed, Le'Kneitah Smith, Tammy Dunsmore, Anita Trichel, Luis A. Ortiz, Kelly Stefano Cole, Eileen Barry. Pneumonic Tularemia in Rabbits Resembles the Human Disease as Illustrated by Radiographic and Hematological Changes after Infection. PLoS ONE, 2001, 6(9): e24654. doi:10.1371/journal.pone.0024654.

           Silvia S. Barbieri, Patrizia Amadio, Sara Gianellini, Elena Zacchi, Babette B. Weksler and Elena Tremoli. Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase. The FASEB Journal, 2011, vol. 25 no. 10 3731-3740.

           Wildaliz Nieves, Saja Asakrah, Omar Qazi, Katherine A. Brown, Jonathan Kurtz, David P. AuCoin, James B. McLachlan, Chad J. Roy, Lisa A. Morici. A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection. Vaccine, Volume 29, Issue 46, 26 October 2011, Pages 8381–8389.

           Brendan Prideaux, Véronique Dartois, Dieter Staab, Danielle M. Weiner, Anne Goh, Laura E. Via, Clifton E. Barry III, and Markus Stoeckli. High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions. Analytical Chemistry, 2011, 83 (6), pp 2112–2118.

           Selvakumar Subbian, Liana Tsenova, Paul O'Brien, Guibin Yang, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Jerome B. Zeldis, George Muller, Gilla Kaplan. Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology. The American Journal of Pathology, Volume 179, Issue 1, July 2011, Pages 289–301.


           Maria C. Kjellssona, Laura E. Via, Anne Goh, Danielle Weiner, Kang Min Low, Steven Kern, Goonaseelan Pillai, Clifton E. Barry III and Véronique Dartois. Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions. Antimicrob. Agents Chemother. January 2012 vol. 56 no. 1 446-45.

           Guoyan Cheng, Xiaomei Yuan, Matthew S. Tsai, Eckhard R. Podack, Aixin Yu and Thomas R. Malek. IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells. The Journal of Immunology August 15, 2012 vol. 189 no. 4 1780-179.

           William R. Kirkpatrick, Laura K. Najvar, Ana C. Vallor, Nathan P. Wiederhold, Rosie Bocanegra, Juergen Pfeiffer, Kimberly Perkins, Alan R. Kugler, Theresa D. Sweeney and Thomas F. Patterson. Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis. J. Antimicrob. Chemother. (2012), 67 (4): 970-976.

           Chad J. Roy, Satheesh K. Sivasubramani, Noton K. Dutta, Smriti Mehra, Nadia A. Golden, Stephanie Killeen, James D. Talton, Badre E. Hammoud, Peter J. Didier and Deepak Kaushal. Aerosolized Gentamicin Reduces the Burden of Tuberculosis in a Murine Model. Antimicrob. Agents Chemother. February 2012, vol. 56, no. 2:883-886.

           Nicole N. Driessen, Helena I. M. Boshoff, Janneke J. Maaskant, Sebastiaan A. C. Gilissen, Simone Vink, Astrid M. van der Sar, Christina M. J. E. Vandenbroucke-Grauls, Carole A. Bewley, Ben J. Appelmelk and Jeroen Geurtsen. Cyanovirin-N Inhibits Mannose-Dependent Mycobacterium–C-Type Lectin Interactions but Does Not Protect against Murine Tuberculosis. The Journal of Immunology October 1, 2012 vol. 189 no. 7 3585-3592.

           Susan T. Gater, Kristen N. Peters, Andrew G. Kocsis, Miqdad O. Dhariwala, Deborah M. Anderson, and Paul E. Anderson. Host stress and immune responses during aerosol challenge of Brown Norway rats with Yersinia pestis. Front Cell Infect Microbiol. 2012; 2: 147.

           Eric R. Secor Jr., Sonali J. Shah, Linda A. Guernsey, Craig M. Schramm, Roger S. Thrall. Bromelain Limits Airway Inflammation in an Ovalbumin-induced Murine Model of Established Asthma. Alternative Therapies in Health & Medicine. Sep/Oct2012, Vol. 18 Issue 5, p9-17. 9p.

           Seth A.Faith, Le'Kneitah P. Smith, Angela S. Swatland, Douglas S. Reed. Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice. Frontiers in Cellular & Infection Microbiology. Sep 2012, Vol. 2, p2-36. 35p.

           S. Paveglio, L. Puddington, E. Rafti and A. P. Matson. FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice. Clinical & Experimental Allergy, Volume 42, Issue 12, pages 1791–1800, December 2012.

           Zhu Li, Gayathri Chadalapaka, Aramandla Ramesh, Habibeh Khoshbouei, Mark Maguire, Stephen Safe, Raina E. Rhoades, Ryan Clark, George Jules, Monique McCallister, Michael Aschner and Darryl B. Hood. PAH Particles Perturb Prenatal Processes and Phenotypes: Protection from Deficits in Object Discrimination Afforded by Dampening of Brain Oxidoreductase Following In Utero Exposure to Inhaled Benzo(a)pyrene. Toxicol. Sci. (2012) 125 (1): 233-247.

           R.S. McDonald, A.R. Sambol, B.K. Heimbuch, T.L. Brown2, S.H. Hinrichs and J.D. Wander. Proportional mouse model for aerosol infection by influenza. Journal of Applied Microbiology, Volume 113, Issue 4, pages 767–778, October 2012.

           Raymond C. Rancourt, Livia A. Veress, XiaoLing Guo, Tara N. Jones, Tara B. Hendry-Hofer, and Carl W. White. Airway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide. Am J Physiol Lung Cell Mol Physiol. Jan 1, 2012; 302(1): L82–L92.

           B.R. Stone, B.K. Heimbuch, C.-Y. Wu and J.D. Wander. Design, construction and validation of a nose-only inhalation exposure system to measure infectivity of filtered bioaerosols in mice. Journal of Applied Microbiology, Volume 113, Issue 4, pages 757–766, October 2012.

           Narayanan Rajendran, Shu-Chieh Hu, Dennis Sullivan, Miguel Muzzio, Carol J. Detrisac, Carmen Venezia. Toxicologic evaluation of tungsten: 28-day inhalation study of tungsten blue oxide in rats. Inhalation Toxicology, December 2012, Vol. 24, No. 14, Pages 985-994.

           Scott Parker, Nanhai G. Chen, Scott Foster, Hollyce Hartzler, Ed Hembrador, Dennis Hruby, Robert Jordan, Randall Lanier, George Painter, Wesley Painter, John E. Sagartz, Jill Schriewer, R. Mark Buller. Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox – An animal model of smallpox. Antiviral Research, Volume 94, Issue 1, April 2012, Pages 44–53.

           Laura E. Via, Dan Schimel, Danielle M. Weiner, Veronique Dartois, Emmanuel Dayao, Ying Cai, Young-Soon Yoon, Matthew R. Dreher, Robin J. Kastenmayer, Charles M. Laymon, J. Eoin Carny, JoAnne L. Flynn, Peter Herscovitch and Clifton E. Barry III. Infection Dynamics and Response to Chemotherapy in a Rabbit Model of Tuberculosis using [18F]2-Fluoro-Deoxy-d-Glucose Positron Emission Tomography and Computed Tomography. Antimicrob. Agents Chemother. August 2012, vol. 56, no. 8:4391-4402.

           Lisa N. Henning, Karen T. Gillum, David A. Fisher, Roy E. Barnewall, Robert T. Krile, Michael S. Anderson, Michael J. Ryan & Richard L. Warren. The Pathophysiology of Inhalational Brucellosis in Balb/c Mice. Sci. Rep. 2, 495; DOI:10.1038/srep00495 (2012).

           Daniel Verreault, Satheesh K. Sivasubramani, James D. Talton, Lara A. Doyle, Joseph D. Reddy, Stephanie Z. Killeen, Peter J. Didier, Preston A. Marx, Chad J. Roy. Evaluation of inhaled cidofovir as postexposure prophylactic in an aerosol rabbitpox model. Antiviral Research, Volume 93, Issue 1, January 2012, Pages 204–208.

           David R. Mattie. et al. Acute, Five- and Ten-Day Inhalation Study of Hydroprocessed Esters and Fatty Acids - Mixed Fats (HEFA-F) Jet Fuel. 2012,

           Sheppard A. Martin, Jerry L. Campbell, Jr., Raphael T. Tremblay, Jeffrey W. Fisher. Development of a physiologically based pharmacokinetic model for inhalation of jet fuels in the rat. Inhalation Toxicology, January 2012, Vol. 24, No. 1, Pages 1-26.


           Raymond C. Rancourt, Livia A. Veress, Aftab Ahmad, Tara B. Hendry-Hofer, Jacqueline S. Rioux, Rhonda B. Garlick, Carl W. White. Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Toxicology and Applied Pharmacology, Volume 272, Issue 1, 1 October 2013, Pages 86–95.

           Laura E. Via, Danielle M. Weiner, Daniel Schimel, Philana Ling Lin, Emmanuel Dayao, Sarah L. Tankersley, Ying Cai, M. Teresa Coleman, Jaime Tomko, Praveen Paripati, Marlene Orandle, Robin J. Kastenmayer, Michael Tartakovsky, Alexander Rosenthal, Damien Portevin, Seok Yong Eum, Saher Lahouar, Sebastien Gagneuxj, Douglas B. Young, JoAnne L. Flynn and Clifton E. Barry III. Differential Virulence and Disease Progression following Mycobacterium tuberculosis Complex Infection of the Common Marmoset (Callithrix jacchus). Infect. Immun. August 2013, vol. 81, no. 8:2909-2919.

           Vladimir Savransky, Daniel C. Sanford, Emily Syar, Jamie L. Austin, Kevin P. Tordoff, Michael S. Anderson, Gregory V. Stark, Roy E. Barnewall, Crystal M. Briscoe, Laurence Lemiale-Biérinx, Sukjoon Park, Boris Ionin and Mario H. Skiadopoulos. Pathology and Pathophysiology of Inhalational Anthrax in a Guinea Pig Model. Infect. Immun. April 2013 vol. 81 no. 4 1152-1163.

           Robert R. Scully, Chiu-Wing Lam, and John T. James. Estimating safe human exposure levels for lunar dust using benchmark dose modeling of data from inhalation studies in rats. Inhalation Toxicology, December 2013, Vol. 25, No. 14, Pages 785-793.

           Chiu-wing Lam, Robert R. Scully, Ye Zhang, Roger A. Renne, Robert L. Hunter, Richard A. McCluskey, Bean T. Chen, Vincent Castranova, Kevin E. Driscoll, Donald E. Gardner, Roger O. McClellan, Bonnie L. Cooper, David S. McKay, Linda Marshall, and John T. James. Toxicity of lunar dust assessed in inhalation-exposed rats. Inhalation Toxicology, October 2013, Vol. 25, No. 12, Pages 661-678.

           Emma L. Beckett, Richard L. Stevens, Andrew G. Jarnicki, Richard Y. Kim, Irwan Hanish, Nicole G. Hansbro, Andrew Deane, Simon Keely, Jay C. Horvat, Ming Yang, MD, Brian G. Oliver, Nico van Rooijen, Mark D. Inman, Roberto Adachi, Roy J. Soberman, Sahar Hamadic, Peter A. Wark, Paul S. Foster, Philip M. Hansbro. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. Journal of Allergy and Clinical Immunology, Volume 131, Issue 3, March 2013, Pages 752–762.

           Vanitha Bhoopalan, Sung Gu Han, Mrudang M. Shah, David M. Thomas, Deepak K. Bhalla. Tobacco smoke modulates ozone-induced toxicity in rat lungs and central nervous system. Inhalation Toxicology, January 2013, Vol. 25, No. 1, Pages 21-28.

           G. Mainelis, S. Seshadri, O.B. Garbuzenko, T. Han, Z. Wang, and T. Minko. Characterization and Application of a Nose-Only Exposure Chamber for Inhalation Delivery of Liposomal Drugs and Nucleic Acids to Mice. Journal of Aerosol Medicine and Pulmonary Drug Delivery. December 2013, 26(6): 345-354.


           Amy L. Hartman, Diana S. Powell, Laura M. Bethel, Amy L. Caroline, Richard J. Schmid, Tim Oury and Douglas S. Reed. Aerosolized Rift Valley Fever Virus Causes Fatal Encephalitis in African Green Monkeys and Common Marmosets. J. Virol. February 2014 vol. 88 no. 4 2235-2245.

           Douglas S. Reed, Le’Kneitah P. Smith, Kelly Stefano Cole, Araceli E. Santiago, Barbara J. Mann and Eileen M. Barry. Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain. Infection and Immunity, April 2014, volume 82, issue 4.

           Maria C. Kjellsson, Laura E. Via, Anne Goh, Danielle Weiner, Kang Min Low, Steven Kern, Goonaseelan Pillai, Clifton E. Barry III and Véronique Dartois. Penetration of anti-tuberculosis agents in rabbit pulmonary lesions: a pharmacokinetic evaluation. Antimicrobial Agents and Chemotherapy, April 2014, volume 58, issue 4.

           Brandon Feinen, Nikolai Petrovsky, Anita Verma and Tod J. Merkel. Advax-Adjuvanted Recombinant Protective Antigen Provides Protection against Inhalational Anthrax That Is Further Enhanced by Addition of Murabutide Adjuvant. Clin Vaccine Immunol, April 2014, vol. 21, no. 4:580-586.

           Olga B. Garbuzenko, Gediminas Mainelis, Oleh Taratula, Tamara Minko. Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention. Cancer Biol Med 2014;11:44-55.

           David E Harrison, Clinton M Astle, M Khalid Khan Niazi, Samuel Major and Gillian L Beamer. Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis. Immunity & Ageing (2014) 11:24, DOI 10.1186/s12979-014-0024-6.

           Xuan Qiu, Yuanxin Liang, Rani S. Sellers, Roman Perez-Soler, Yiyu Zou. Aerosol Azacytidine Inhibits Orthotopic Lung Cancers in Mice through Its DNA Demethylation and Gene Reactivation Effects. PLoS ONE 9(10): e109874. doi:10.1371/journal.pone.0109874.

           Sasha J. Rose, Mary E. Neville, Renu Gupta, Luiz E. Bermudez. Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection. PLoS ONE 9(9): e108703. doi:10.1371/journal.pone.0108703.

           Simone R. Carvalho, Alan B. Watts, Jay I. Peters, Sha Liua, Soraya Hengsawas, Manuel S. Escotet-Espinoza, Robert O. Williams III. Characterization and pharmacokinetic analysis of crystalline versus amorphous Rapamycin dry powder via pulmonary administration in rats. European Journal of Pharmaceutics and Biopharmaceutics, Volume 88, Issue 1, Pages 136–147, September 2014.


           Richard McClure, Daijiro Yanagisawa, Donald Stec, Dave Abdollahian, Dmitry Koktysh, Dritan Xhillari, Rudolph Jaeger, Gregg Stanwood, Eduard Chekmenev, Ikuo Tooyama, John C Gore, Wellington Pham. Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer's disease. J Alzheimers Dis. 2015 ;44(1):283-95.

           Paul R. Houin, Livia A. Veress, Raymond C. Rancourt, Tara B. Hendry-Hofer, Joan E. Loader, Jacqueline S. Rioux, Rhonda B. Garlick and Carl W. White. Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatric Pulmonology, Volume 50, Issue 2, pages 118–126, February 2015.

           Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt. Prostacyclin Compounds, Compositions and Methods of Use Thereof. INSMED INCORPORATED, 20150175529,

           Mugimane G. Manjanathaa , Sharon D. Sheltona, Lynne Haberb, Bhaskar Gollapudic, Judith A, MacGregord, Narayanan Rajendrane, Martha M. Moorea. Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Elsevier, 29 June 2015, doi:10.1016/j.mrgentox.2015.06.014.

           Niazi MK, Dhulekar N, Schmidt D, Major S, Cooper R, Abeijon C, Gatti D, Kramnik I, Yener B, Gurcan M, Beamer G. Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune competent mice. Dis Model Mech, July 23 2015. DOI: 10.1242/dmm.020867.

           Paul M. Beringer, Timothy J. Bensman, Henry Ho, Melissa Agnello, Nicole Denovel, Albert Nguyen, Annie Wong-Beringer, Rosemary She, Dat Q. Tran, Samuel M. Moskowitz, and Michael E. Selsted. Rhesus u-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, October 3, 2015. DOI:10.1093/jac/dkv301.

           Carl W. White, Livia A. Veress. Treatment for Airway CAST Obstruction. National Jewish Health, November 12, 2015. United States Patent Application 20150322421.


            Donald J. Girouard Jr. and Mark A. Czarneski. Room, Suite Scale, Class III Biological Safety Cabinet, and Sensitive Equipment Decontamination and Validation Using Gaseous Chlorine Dioxide. Applied Biosafety, April 7, 2016. DOI: 10.1177/1535676016638750.

            Selvakumar Subbian, Liana Tsenova, Jennifer Holloway, Blas Peixoto, Paul O'Brien, Véronique Dartois, Vikram Khetani, Jerome B. Zeldis, Gilla Kaplan. Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model. EBioMedicine, January 24, 2016 DOI:

            Michael S. Werley, Dan J. Kirkpatrick, Michael J. Oldham, Ann M. Jerome, Timothy B. Langston, Patrick D. Lilly, Donna C. Smith, Willie J. Mckinney Jr. Toxicological Assessment of a Prototype E-cigaret Device and Three Flavor Formulations: a 90-day Inhalation Study in Rats. Inhalation Toxicology: International Forum for Respiratory Research, January 20, 2016 DOI:10.3109/08958378.2015.1130758.

            Bennett J. Doughty. The Potentiating Effects of Acetaminophen on Oxidant Air Pollutant Sensory Irritation and the Onset of Asthma. Honors Scholar Theses, May 1, 2016

            Gang Liu, Marion A. Cooley, Andrew G. Jarnicki, Alan C-Y. Hsu, Prema M. Nair, Tatt Jhong Haw, Michael Fricker, Shaan L. Gellatly, Richard Y. Kim, Mark D. Inman, Gavin Tjin, Peter A.B. Wark, Marjorie M. Walker, Jay C. Horvat, Brian G. Oliver, W. Scott Argraves, Darryl A. Knight, Janette K. Burgess, Philip M. Hansbro. Fibulin-1 Regulates the Pathogenesis of Tissue Remodeling in Respiratory Diseases. JCI Insight, June 16, 2016 DOI:10.1172/jci.insight.86380.

           de Beer, F., Lagrand, W., Glas, G.J. et al. Nebulized C1-Esterase Inhibitor does not Reduce Pulmonary Complement Activation in Rats with Severe Streptococcus Pneumoniae Pneumonia. Cell Biochem Biophys, September 2016 DOI:10.1007/s12013-016-0766-1

           Husari, A., Hashem, Y., Bitar, H., Dbaibo, G., Zaatari, G., & El Sabban, M. Antioxidant activity of pomegranate juice reduces emphysematous changes and injury secondary to cigarette smoke in an animal model and human alveolar cells. International Journal of Chronic Obstructive Pulmonary Disease, February 2016 DOI:10.2147/COPD.S97027

           Ahmad Husari, Alan Shihadeh, Soha Talih, Yasmine Hashem, Marwan El Sabban, and Ghazi Zaatari. Acute Exposure to Electronic and Combustible Cigarette Aerosols: Effects in an Animal Model and in Human Alveolar Cells. Nicotine Tob Res (2016) DOI:10.1093/ntr/ntv169


            David M. Ryckman, Iching G. Yu. (2017) US Patent Application No. 20170049846.

            Marina P. Sutunkova, Svetlana N. Solovyeva, Boris A. Katsnelson, Vladimir B. Gurvich, Larisa I. Privalova, Ilzira A. Minigalieva, Tatyana V. Slyshkina, Irene E. Valamina, Oleg H. Makeyev, Vladimir Ya. Shur, Ilya V. Zubarev, Dmitry K. Kuznetsov, and Ekaterina V. Shishkina. A paradoxical response of the rat organism to long-term inhalation of silica-containing submicron (predominantly nanoscale) particles of a collected industrial aerosol at realistic exposure levels. Toxicology, April 2017 DOI: 10.1016/j.tox.2017.04.010.

            Anthony M Cadena. Decoding Early Immune Events in Non-human Primates Infected with Mycobacterium tuberculosis. Doctoral Dissertation, 2017.

            Nataliia Kovalchuk, Jacklyn Kelty, Lei Li, Matthew Hartog, Qing-Yu Zhang, Patricia Edwards, Laura Van Winkle, Xinxin Ding. Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene. Toxicology and Applied Pharmacology, May 2017. DOI:10.1016/j.taap.2017.05.015.

            Lei Li, Sarah Carratt, Matthew Hartog, Nataliia Kovalchuk, Kunzhi Jia, Yanan Wang, Qing-Yu Zhang, Patricia Edwards, Laura Van Winkle, and Xinxin Ding. Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice. Environ Health Perspect, June 2017. DOI:10.1289/EHP844.

            Zhili Li, Richard Chapman, Vladimir Malinin, Michel Corboz, Helena Gauani, Charles Laurent, Han Yin, Dany Salvail, Walter Perkins, and Adam Plaunt. Pharmacokinetic (PK) Comparison Between Nebulized and Dry Powder INS1009 in Rats. Am. J. Respir. Crit. Care Med., 2017 DOI: 195:A4200.

            Xuesi Max Shao, Hector E. Lopez-Valdes, Jing Liang, Jack L. Feldman. Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats. BioRxiv, September 2017. DOI:10.1101/195099.

            Xuesi Max Shao, Siyu Liu, Eon S Lee, David Fung, Hua Pei, Jing Liang, Ross Mudgway, Jingxi Zhang, Jack L Feldman, Yifang Zhu, Stan Louie, Xinmin S Xie. Chronic intermittent nicotine delivery with lung alveolar region-targeted aerosol technology produces circadian blood pharmacokinetics in rats resembling human smokers BioRxiv, September 2017. DOI:10.1101/195123.

            Susan M. DeLeon, Jason D. Downey, Diane M. Hildenberger, Melissa O. Rhoomes, Lamont Booker, Gary A. Rockwood & Kelly A. Basi. DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice. Clinical Toxicology, September 2017. DOI:10.1080/15563650.2017.1376749.

            David M. Ryckman, Iching G. Yu. Methods of treating lung infection with caspofungin. US Patent Office, February 2017. USPTO Applicaton #: #20170049846, Trilogy Therapeutics, Inc. patents.


            Parth N. Shah, Kimberly R. Marshall Batty, Justin A. Smolen, Jasur A. Tagaev, Qingquan Chen, Christopher A. Rodesney, Henry H. Le, Vernita D. Gordon, David E. Greenberg, Carolyn L. Cannon. Antimicrobial Activity of Ibuprofen Against Cystic Fibrosis Associated Gram-Negative Pathogens. Antimicrob Agents Chemother, January 2018. DOI: 10.1128/AAC.01574-17.

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