E-Cigarette Aerosol Generator (ECAG)


            Smruti Pushalkar, Bidisha Paul, Qianhao Li, Jian Yang, Rebeca Vasconcelos, Shreya Makwana, Juan Munoz Gonzale, Shivm Sha, Chengzhi Xi, Malvin N. Janal, Erica Queiroz, Maria Bederoff, Joshua Leinwand, Julia Solarewicz, Fangxi Xu, Eman Aboseria, Yuqi Guo, Deanna Aguallo, Claudia Gomez, Angela Kamer, Donna Shelley, Yindalon Aphinyanaphongs, Cheryl Barber, Terry Gordon, Patricia Corby, Xin Li, and Deepak Saxena. Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection. Iscience Feb. 2020.

            Goniewicz et al. An Animal Model of Inhaled Vitamin E Acetate and EVALI-like Lung Injury. New England Journal of Medicine, Feb 2020

            Zelikoff & Schwartzer et al. Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols. Environmental Health Perspectives, April 2020.


            Yuan-Wan Sun,Wieslawa Kosinska , Joseph B. Guttenplan. E-cigarette Aerosol Condensate Enhances Metabolism of Benzo(a)pyrene to Genotoxic Products, and Induces CYP1A1 and CYP1B1, Likely by Activation of the Aryl Hydrocarbon Receptor. Int Journal Environmental Research & Public Health, July 2019.

            Moon-shong Tang, Xue-Ru Wu, Hyun-Wook Lee, Yong Xia, Fang-Ming Deng, Andre L. Moreira, Lung-Chi Chen, William C. Huang, and Herbert Lepor. Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proceedings of the National Academy of Sciences (PNAS), Oct. 2019

            O. Orimoloye, S M Uddin, LC Chen, A. Osei, M. Mirbolouk, M. Malovichko, I. D Sithu, O. Dzaye, D. Conklin, S. Srivastava, M. Blaha. Electronic cigarettes and insulin resistance in animals and humans: Results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016). PLOS ONE Dec. 2019


            Hyun-Wook Lee, Sung-Hyun Park, Mao-wen Weng, Hsiang-Tsui Wang, William C. Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen and Moon-shong Tang. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proceedings of the National Academy of Sciences (PNAS), Jan. 2018.

            Jiayuan Zhao, Yipei Zhang, Jennifer D. Sisler, Justine Shaffer, Stephen S. Leonard, Anna M. Morris, Yong Qian, Dhimiter Bello, Philip Demokritou. Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches. Journal of Hazardous Materials, Feb. 2018.

            Jiayuan Zhao, Jordan Nelson, Oluwabunmi Dada, Georgios Pyrgiotakis, IliasG. Kavouras & Philip Demokritou. Assessing electronic cigarette emissions: linking physico-chemical properties to product brand, e-liquid flavoring additives, operational voltage and user puffing patterns. Inhalation Toxicology, DOI: 10.1080/08958378.2018.1450462, 2018.


            Marina V Malovichko, Abhinav Agarwal, Millicent Winner, Michel Smith, Srinivas Sithu, Terry Gordon, Aruni Bhatnagar, Daniel Conklin, Lung-Chi Chen, Sanjay Srivastava. Effect of Electronic Cigarettes on Cardiovascular Health. [Meeting Abstract] Arteriosclerosis, Thrombosis, and Vascular Biology, August 2017.

            Hyun-Wook Lee, Sung-Hyun Park, Mao-wen Weng, Hsing-Tsui Wang, William Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, Moon-shong Tang. PNFBA-11 E-cigarette Smoke is Potentially Bladder Carcinogenic – It Induces Tumorigenic DNA Adducts and Inhibits DNA Repair in Urothelial Cells. [Meeting Abstract] The Journal of Urology, April 2017.

            Judith T Zelikoff, Nancy Parmalee, Kevin Corbett, Terry Gordon, Catherine B Klein, Michael Aschner. Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early Life Exposure to E-cigarette Aerosols in a Murine Model. Toxicological Sciences, Nov. 2017


           Dana E. Lauterstein, Pamella B. Tijerina, Kevin Corbett, Betul Akgol Oksuz, Steven S. Shen, Terry Gordon, Catherine B. Klein, and Judith T. Zelikoff. Frontal Cortex Transcriptome Analysis of Mice Exposed to Electronic Cigarettes During Early Life Stages. Internation Journal of Environmental Research and Public Health, April 2016, DOI: 10.3390/ijerph13040417.

            Lauterstein, D. E., Tijerina, P. B., Corbett, K., Gordon, T., Aschner, M., Parmalee, N., Conrad, K., Allen, J., Cory-Slechta, D., Zelikoff, J. T., Klein, C. B. E-Cigarette Aerosols Induce Neurobiological and Neurobehavioral Alterations in Mice Exposed during Early Life [Meeting Abstract]. Environmental & Molecular Mutagenesis, September 2016. 57:S81-S81.

           Jiayuan Zhao, Georgios Pyrgiotakis & Philip Demokritou. Development and characterization of electronic-cigarette exposure generation system (Ecig-EGS) for the physico-chemical and toxicological assessment of electronic cigarette emissions. Inhalation Toxicology, November 10, 2016 DOI:10.1080/08958378.2016.1246628.

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