JB Series Automatic Smoking Machines


           T. H. Thatcher, N. A. McHugh, R. W. Egan, R. W. Chapman, J. A. Hey, C. K. Turner, M. R. Redonnet, K. E. Seweryniak, P. J. Sime, and R. P. Phipps. The Role of CXCR2 in Cigarette Smoke-Induced Lung Inflammation. Am J Physiol Lung Cell Mol Physiol. Aug 2005; 289(2): L322–L328.


           Sheung P. Ng, Allen E. Silverstone, Zhi-Wei Lai and Judith T. Zelikoff. Effects of Prenatal Exposure to Cigarette Smoke on Offspring Tumor Susceptibility and Associated Immune Mechanisms. Toxicol. Sci. (January 2006) 89 (1): 135-144.

           Aruna Kode, Se-Ran Yang and Irfan Rahman. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respiratory Research, 2006, Vol.7:132.

           Roger A. Renne, Hiroyuki Yoshimura, Kei Yoshino, George Lulham, Susumu Minamisawa, Albrecht Tribukait, Dennis D. Dietz, Kyeonghee Monica Lee and R. Bruce Westerberg. Effects of Flavoring and Casing Ingredients on the Toxicity of Mainstream Cigarette Smoke in Rats. Inhalation Toxicology, 2006, Vol. 18, No. 9, Pages 685-706.


           Se-Ran Yang, Jessica Wright, Mark Bauter, Kathryn Seweryniak, Aruna Kode, Irfan Rahman. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. American Journal of Physiology - Lung Cellular and Molecular Physiology, February 2007, Vol. 292, no. L567-L576.

           Thomas H. Thatcher, Sanjay B. Maggirwar, Carolyn J. Baglole, Heather F. Lakatos, Thomas A. Gasiewicz, Richard P. Phipps, Patricia J. Sime. Aryl Hydrocarbon Receptor-Deficient Mice Develop Heightened Inflammatory Responses to Cigarette Smoke and Endotoxin Associated with Rapid Loss of the Nuclear Factor-κB Component RelB. The American Journal of Pathology, Volume 170, Issue 3, March 2007, Pages 855–864.

           Christine Nadziejko, Kaije Fang, Antonio Bravo, and Terry Gordon. Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke. Journal of Applied Physiology, May 2007, vol. 102, no. 5, 1780-1785.

           Ying Yan, Qing Tan, Yian Wang, Daolong Wang, Mike Jin, Terry Gordon, Ronald A. Lubet and Ming You. Enhanced Lung Tumor Development in Tobacco Smoke-Exposed p53 Transgenic and Kras2 Heterozygous Deficient Mice. Inhalation Toxicology, 2007, Vol. 19, No. s1, Pages 183-187.


           Se-Ran Yang, Samantha Valvo, Hongwei Yao, Aruna Kode, Saravanan Rajendrasozhan, Indika Edirisinghe, Samuel Caito, David Adenuga, Ryan Henry, George Fromm, Sanjay Maggirwar, Jian-Dong Li, Michael Bulger, and Irfan Rahman. IKKα Causes Chromatin Modification on Pro-Inflammatory Genes by Cigarette Smoke in Mouse Lung. Am J Respir Cell Mol Biol. Jun 2008; 38(6): 689–698.

           Thomas H. Thatcher, Randi P. Benson, Richard P. Phipps, and Patricia J. Sime. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. American Journal of Physiology - Lung Cellular and Molecular Physiology, Sep 2008; 295(3): L412-L421.

           Hongwei Yao, Indika Edirisinghe, Se-Ran Yang, Saravanan Rajendrasozhan, Aruna Kode, Samuel Caito, David Adenuga, Irfan Rahman. Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice. The American Journal of Pathology, Volume 172, Issue 5, May 2008, Pages 1222–1237.

           Hongwei Yao, Se-Ran Yang, Indika Edirisinghe, Saravanan Rajendrasozhan, Samuel Caito, David Adenuga, Michael A. O'Reilly, and Irfan Rahman. Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice. Am J Respir Cell Mol Biol. Jul 2008; 39(1): 7–18.

           Robert Fountaine, Ashley Milton, Tina Checchio, Greg Wei, Marilyn Stolar, John Teeter, Rudolph Jaeger and David Fryburg. Acute passive cigarette smoke exposure and inhaled human insulin (Exubera®) pharmacokinetics. British Journal of Clinical Pharmacology, Volume 65, Issue 6, pages 864–870, June 2008.

           Indika Edirisinghe, Se-Ran Yang, Hongwei Yao, Saravanan Rajendrasozhan, Samuel Caito, David Adenuga, Chelsea Wong, Arshad Rahman, Richard P. Phipps, Zheng-Gen Jin and Irfan Rahman. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. The FASEB Journal, July 2008, vol. 22, no. 7:2297-2310.

           Oliver J. Harrisona, Joseph Foley, Brian J. Bolognese, Edward Long III, Patricia L. Podolin, Patrick T. Walsh. Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunology Letters, Volume 121, Issue 1, 16 November 2008, Pages 13–21.

           Hongwei Yao , Indika Edirisinghe , Saravanan Rajendrasozhan , Se-Ran Yang , Samuel Caito , David Adenuga , Irfan Rahman. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. American Journal of Physiology - Lung Cellular and Molecular Physiology, June 2008, Vol. 294, no. L1174-L1186.

           Sheung P. Ng and Judith T. Zelikoff. The Effects of Prenatal Exposure of Mice to Cigarette Smoke on Offspring Immune Parameters. Journal of Toxicology and Environmental Health, Part A: Current Issues, Volume 71, Issue 7, 2008.


           Se-Ran Yang, Hongwei Yao, Saravanan Rajendrasozhan, Sangwoon Chung, Indika Edirisinghe, Samantha Valvo, George Fromm, Michael J. McCabe, Jr., Patricia J. Sime, Richard P. Phipps, Jian-Dong Li, Michael Bulger and Irfan Rahman. RelB Is Differentially Regulated by IκB Kinase-α in B Cells and Mouse Lung by Cigarette Smoke. Am J Respir Cell Mol Biol, Feb 2009, 40(2):147-158.

           John T. Bernert, Sydney M. Gordon, Ram B. Jain, Marielle C. Brinkman, Connie S. Sosnoff, Tiffany H. Seyler, Yang Xia, James E. McGuffey, David L. Ashley, James L. Pirkle, Eric J. Sampson. Increases in tobacco exposure biomarkers measured in non-smokers exposed to side stream cigarette smoke under controlled conditions. Biomarkers, March 2009, Vol. 14, No. 2, Pages 82-93.

           Michelle Natiello, George Kelly, James Lamca, David Zelmanovic, Richard W. Chapman, Jonathan E. Phillips. Manual and automated leukocyte differentiation in bronchoalveolar lavage fluids from rodent models of pulmonary inflammation. Comparative Clinical Pathology, May 2009, Volume 18, Issue 2, pp 101-111.

           Sheung P. Ng, Daniel J. Conklin, Aruni Bhatnagar, Duane D. Bolanowski, Jessica Lyon, and Judith T. Zelikoff. Prenatal Exposure to Cigarette Smoke Induces Diet- and Sex-Dependent Dyslipidemia and Weight Gain in Adult Murine Offspring. Environ Health Perspect. Jul 2009; 117(7): 1042–1048.

           Terry Gordon, Maarten Bosland. Strain-dependent differences in susceptibility to lung cancer in inbred mice exposed to mainstream cigarette smoke. Cancer Letters, Volume 275, Issue 2, 18 March 2009, Pages 213–220.

           Elizabeth M. Vancza, Sheung Pui Ng, Jack R. Harkema, Judith T. Zelikoff. The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms. Journal of Immunotoxicology, June 2009, Vol. 6, No. 2, Pages 94-103.


           Saravanan Rajendrasozhan, Sangwoon Chung, Isaac K. Sundar, Hongwei Yao, and Irfan Rahman. Targeted disruption of NF-κB1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. American Journal of Physiology - Lung Cellular and Molecular Physiology, Feb 2010; 298(2): L197-L209.

           David Adenuga, Samuel Caito, Hongwei Yao, Isaac K. Sundar, Jae-Woong Hwang, Sangwoon Chung, Irfan Rahman. Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochemical and Biophysical Research Communications, Volume 403, Issues 3–4, 17 December 2010, Pages 452–456.

           Saravanan Rajendrasozhan, Jae-Woong Hwang, Hongwei Yao, Nandini Kishore, Irfan Rahman. Anti-inflammatory effect of a selective IκB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulmonary Pharmacology & Therapeutics, Volume 23, Issue 3, June 2010, Pages 172–181.

           Gnanapragasam Arunachalam, Isaac K Sundar, Jae-woong Hwang, Hongwei Yao and Irfan Rahman. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. Journal of Inflammation 2010, 7:34 doi: 10.1186/1476-9255-7-34.

           Hongwei Yao, Jae-woong Hwang, Jorge Moscat, Maria T. Diaz-Meco, Michael Leitges, Nandini Kishore, Xiong Li and Irfan Rahman. Protein Kinase Cζ Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications. The Journal of Biological Chemistry, 2010, 285, 5405-5416.

           Jae-woong Hwang, Sangwoon Chung, Isaac K. Sundar, Hongwei Yao, Gnanapragasam Arunachalam, Michael W. McBurney, Irfan Rahman. Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD. Archives of Biochemistry and Biophysics, Volume 500, Issue 2, 15 August 2010, Pages 203–209.

           Sangwoon Chung, Isaac Kirubakaran Sundar, Hongwei Yao, Ye-Shih Ho, and Irfan Rahman. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of IκB kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol. Aug 2010; 299(2): L192–L203.

           Isaac K. Sundar, Sangwoon Chung, Jae-Woong Hwang, Gnanapragasam Arunachalam, Suzanne Cook, Hongwei Yao, Witold Mazur, Vuokko L. Kinnula, Aron B. Fisher, and Irfan Rahman. Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury. Experimental Lung Research, October 2010, Vol. 36, No. 8, Pages 451-462.

           Samuel Caito, Saravanan Rajendrasozhan, Suzanne Cook, Sangwoon Chung, Hongwei Yao, Alan E. Friedman, Paul S. Brookes and Irfan Rahman. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. The FASEB Journal, September 2010, vol. 24 no. 9 3145-3159.


           Sangwoon Chung, Isaac K. Sundar, Jae-Woong Hwang, Fiona E. Yull, Timothy S. Blackwell, Vuokko L. Kinnula, Michael Bulger, Hongwei Yao, Irfan Rahman. NF-κB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFα-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs. PLoS ONE, 2011, 6(8): e23488.doi:10.1371/journal.pone.0023488.

           Yanjun Wu, Charles J. Kotzer, Sokratis Makrogiannis, Gregory A. Logan, Hyking Haley, Mary S. Barnette, Susanta K. Sarkar. A Noninvasive [99mTc] DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD. Molecular Imaging and Biology, October 2011, Volume 13, Issue 5, pp 923-929.

           Hongwei Yao, Irfan Rahman. Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vitro in Preclinical Models, and in Smokers and Patients with Airways Disease. Studies on Experimental Models, Oxidative Stress in Applied Basic Research and Clinical Practice, 2011, pp 399-420.

           David H. McMillan, Carolyn J. Baglole, Thomas H. Thatcher, Sanjay Maggirwar, Patricia J. Sime, Richard P. Phipps. Lung-Targeted Overexpression of the NF-κB Member RelB Inhibits Cigarette Smoke–Induced Inflammation. The American Journal of Pathology, Volume 179, Issue 1, July 2011, Pages 125–133.

           Jae-woong Hwang, Saravanan Rajendrasozhan, Hongwei Yao, Sangwoon Chung, Isaac K Sundar, Heidie L Huyck, Gloria S Pryhuber, Vuokko L Kinnula, Irfan Rahman. Journal of Immunology, Jul 2011, vol. 187, no. 2:987-998.


           Isaac K. Sundar, Sangwoon Chung, Jae-woong Hwang, John D. Lapek Jr., Michael Bulger, Alan E. Friedman, Hongwei Yao, James R. Davie and Irfan Rahman. Mitogen- and Stress-Activated Kinase 1 (MSK1) Regulates Cigarette Smoke-Induced Histone Modifications on NF-κB-dependent Genes. PLoS ONE, 2012, 7(2): e31378. doi:10.1371/journal.pone.0031378.


           Patricia L. Podolin , Joseph P. Foley , Donald C. Carpenter , Brian J. Bolognese , Gregory A. Logan , Edward Long III, Oliver J. Harrison , Patrick T. Walsh. T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice. American Journal of Physiology - Lung Cellular and Molecular Physiology, March 2013, Vol. 304 no. L312-L323.

           Thomas H. Thatcher , Hsi-Min Hsiao , Elhanan Pinner , Moshe Laudon , Stephen J. Pollock , Patricia J. Sime, Richard P. Phipps. Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. American Journal of Physiology - Lung Cellular and Molecular Physiology, July 2013, Vol. 305no. L165-L174.

           Jill C Todt, Christine M Freeman, Jeanette P Brown, Joanne Sonstein, Theresa M Ames, Alexandra L McCubbrey, Fernando J Martinez, Stephen W Chensue, James M Beck and Jeffrey L Curtis. Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. Respiratory Research 2013, 14:33.


           Carrie Yochum, Shannon Doherty-Lyon, Carol Hoffman, Muhammad M. Hossain, Judith T. Zelikoff, Jason R. Richardson. Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: Role of altered catecholamines and BDNF. Experimental Neurology, Volume 254, April 2014, Pages 145–152.

           Jae-Woong Hwang, Isaac K. Sundar, Hongwei Yao, Michael T. Sellix and Irfan Rahman. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. The FASEB Journal, 2014, vol. 28 no. 1 176-194.

           Isaac K. Sundar, Hongwei Yao, Yadi Huang, Elizabeth Lyda, Patricia J. Sime, Michael T. Sellix, Irfan Rahman. Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis. PLoS ONE 9(2): e87999, 2014.

           Amit A. Lugade, Paul N. Bogner, Thomas H. Thatcher, Patricia J. Sime, Richard P. Phipps and Yasmin Thanavala. Cigarette Smoke Exposure Exacerbates Lung Inflammation and Compromises Immunity to Bacterial Infection. The Journal of Immunology, Published April 21, 2014, doi:10.4049/jimmunol.1302584, 2014.


           Hitoshi Fujimoto, Hiroyuki Tsuji, Chigusa Okubo, Ichiro Fukuda, Tomoki Nishino, K. Monica Lee, Roger Renne, and Hiroyuki Yoshimura. Biological responses in rats exposed to mainstream smoke from a heated cigarette compared to a conventional reference cigarette. Inhal Toxicol, doi:10.3109/08958378.2015.1027799.

           Swati Kumar, Tamar A. Smith-Norowitz, Stephan Kohlhoff, Petra Apfalter, Patricia Roblin, Andrei Kutlin, Jack Harkema, Sheung P. Ng, Shannon Doherty-Lyons, Judith T. Zelikoff, and Margaret R. Hammerschlag. Exposure to cigarette smoke and Chlamydia pneumoniae infection in mice: Effect on infectious burden, systemic dissemination and cytokine responses: A pilot study. Journal of Immunotoxicology, 2015, doi:10.3109/1547691X.2015.1006346.

           Hu JZ, Wang X, Feng J , Robertson BJ , Waters KM , Tilton SC , Pounds JG , Corley RA , Liu M and Hu M. Metabolite Signatures in Hydrophilic Extracts of Mouse Lungs Exposed to Cigarette Smoke Revealed by 1H NMR Metabolomics Investigation. Metabolomics 5: 143. doi:10.4172/2153-0769.1000143.

           Thomas E. Sussan, Sachin Gajghate, Rajesh K. Thimmulappa, Jinfang Ma, Jung-Hyun Kim, Kuladeep Sudini, Nicola Consolini, Stephania A. Cormier, Slawo Lomnicki, Farhana Hasan, Andrew Pekosz, Shyam Biswal. Exposure to Electronic Cigarettes Impairs Pulmonary Anti-Bacterial and Anti-Viral Defenses in a Mouse Model. February 4, 2015. DOI: 10.1371/journal.pone.0116861.


            Kyung-Hwa Chang, Jung-Min Park, Chang Hoon Lee, Bumseok Kim, Kyung-Chul Choi, Seong-Jin Choi, Kyuhong Lee, Moo-Yeol Lee. NADPH oxidase (NOX) 1 mediates cigarette smoke-induced superoxide generation in rat vascular smooth muscle cells. Toxicology in Vitro, February 2017 DOI: 10.1016/j.tiv.2016.10.013.

            Jong Won Kim, Hyejin Yun, Seong-Jin Choi, Sang-Hyub Lee, Surim Park, Chae Woong Lim, Kyuhong Lee, Bumseok Kim. Evaluating the Influence of Side Stream Cigarette Smoke at an Early Stage of Non-Alcoholic Steatohepatitis Progression in Mice. Toxicol Res., January 2017 DOI: 10.5487/TR.2017.33.1.031.

            Perry Iain A., Sexton Keith J., Prytherch Zoë C., Blum Jason L., Zelikoff Judith T., and BéruBé Kelly A. An In Vitro Versus In Vivo Toxicogenomic Investigation of Prenatal Exposures to Tobacco Smoke. Applied In Vitro Toxicology, May 2017 DOI: aivt.2016.0041.

            Anne M. Manicone, Sina A. Gharib, Ke-Qin Gong, William E. Eddy, Matthew E. Long, Charles W. Frevert, William A. Altemeier, William C. Parks, A. McGarry Houghton. Matrix Metalloproteinase-28 Is a Key Contributor to Emphysema Pathogenesis. Pathology, June 2017. DOI:10.1016/j.ajpath.2017.02.008.


            Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM. Chronic cigarette smoke exposure drives spinal ganglion neuron loss in mice. 2018 Apr 10;8(1):5746. doi: 10.1038/s41598-018-24166-9.

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