Nose-Only Inhalation Exposure Systems

In inhalation exposure studies it is generally preferable to avoid or limit confounding exposure routes through ingestion, dermal absorption, and other non-respiratory pathways. This is achieved by using inhalation systems that are designed to expose only the breathing zone of the exposure subjects to the test atmosphere. The main advantages of the nose-only exposure method are:

  • Minimize the amount of test article generated to achieve a certain dose
  • Avoids alternative exposure routes
  • Eliminates potential eye irritation
  • Precise control of exposure for each individual animal
  • Concentration in the exposure chamber can be rapidly changed

The CH Technologies Nose-Only Inhalation Exposure Systems (NOIES)* employ our patented flow-directed design to deliver precisely controlled doses to the breathing zone of the exposure subjects with minimal rebreathing of the test article. Our specially designed animal restrainers are world renown for the comfort they provide to the animals during the exposures with their ability to reduce physical stress and heat buildup.

Fresh test atmosphere is provided to each animal from the inner plenum and exhausted into the space between the inner and the outer plenum. The test aerosol, gas, or vapor that flows through the inner plenum is distributed uniformly to the test subject through the trumpet. Validation tests performed by various research groups have consistently confirmed the homogeneity of the aerosol distribution in the chamber.

Depending on the nature and toxicity of the test article, the CH Nose-Only Inhalation Exposure Systems (NOIES)* can run under positive pressure with open restraint tubes or, for highest containment, under negative pressure, with sealed restraint tubes.

For any species from rodents to non-human primates and for any test article in liquid, powder, or gas form, our skilled engineering team will custom design and build a turn-key nose-only system that will meet the requirements of your application.

Hundreds of peer-reviewed publications from around the world that feature work carried out with the CH Nose-Only Inhalation Exposure Systems (NOIES)* offer compelling testimony to CH Technologies’ proven track record of delivering what each CH customer needs.

*(NOIES) Nose-Only Inhalation Exposure Systems

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